5-BroMo-2-fluoro-4-Methylbenzonitrile

Base Information

• Chemical Name: 5-BroMo-2-fluoro-4-Methylbenzonitrile
• CAS No.: 1269493-45-9
• Molecular Formula: C₈H₅BrFN
• Molecular Weight: 214.037
• Hs Code.: 2926907090
• Mol file: 1269493-45-9.mol

Synonyms:5-BroMo-2-fluoro-4-Methylbenzonitrile

Chemical Property of 5-BroMo-2-fluoro-4-Methylbenzonitrile

Chemical Property:

• Boiling Point: 254.9±35.0 °C(Predicted)
• PSA: 23.79000
• Density: 1.59±0.1 g/cm3(Predicted)
• LogP: 2.76828
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-2-fluoro-4-methylbenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BroMo-2-fluoro-4-Methylbenzonitrile

There total 1 articles about 5-BroMo-2-fluoro-4-Methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-bromo-2-fluoro-4-methyl-benzaldehyde (497224-12-1) → 5-bromo-2-fluoro-4-methylbenzonitrile (1269493-45-9)

Guidance literature:

With hydroxylamine-O-sulfonic acid; In water; at 50 ℃; for 16h;

Reference yield: 43.0%

5-bromo-2-fluoro-4-methylbenzonitrile (1269493-45-9) → 5-bromo-4-(bromomethyl)-2-fluorobenzonitrile

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; at 85 ℃; for 16h;

Reference yield:

5-bromo-2-fluoro-4-methylbenzonitrile (1269493-45-9) → 5-bromo-4-((3,4-dichlorophenoxy)methyl)-2-fluorobenzonitrile

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 16 h / 85 °C

2: potassium carbonate / acetone / 2 h / 50 °C

With N-Bromosuccinimide; potassium carbonate; dibenzoyl peroxide; In tetrachloromethane; acetone;

upstream raw materials:

5-bromo-2-fluoro-4-methyl-benzaldehyde

Refernces