(2R)-2-Amino-2-methyl-1-butanol

Base Information

• Chemical Name: (2R)-2-Amino-2-methyl-1-butanol
• CAS No.: 22464-37-5
• Molecular Formula: C₅H₁₃NO
• Molecular Weight: 103.164
• Mol file: 22464-37-5.mol

Synonyms:(+)-D-Isovalinol;(2R)-2-Amino-2-methyl-1-butanol;[R,(+)]-2-Amino-2-methyl-1-butanol;D-Isovalinol

Chemical Property of (2R)-2-Amino-2-methyl-1-butanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-Amino-2-methyl-1-butanol

There total 12 articles about (2R)-2-Amino-2-methyl-1-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

DL-isovaline (595-39-1,465-58-7) → 2-amino-2,3-dimethyl-1-propanol (10196-30-2,22464-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl

2: LiAlH₄ / diethyl ether

With hydrogenchloride; lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1021/jm00324a027

Reference yield:

2-(4-methoxybenzyl)amino-2-methylbut-3-en-1-ol → (S)-2-amino-2-methylbutan-1-ol (22464-36-4,22464-37-5) + (R)-2-amino-2-methylbutan-1-ol (10196-30-2,22464-37-5)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; at 20 ℃; for 20h; under 4137.18 Torr; Title compound not separated from byproducts;

DOI:10.1055/s-2005-918443

Reference yield:

2-(4-methoxybenzyl)amino-2-methylbut-3-en-1-ol → (S)-2-amino-2-methylbutan-1-ol (22464-36-4,22464-37-5) + (R)-2-amino-2-methylbutan-1-ol (10196-30-2,22464-37-5)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; at 20 ℃; for 20h; under 4137.18 Torr; Title compound not separated from byproducts;

DOI:10.1055/s-2005-918443

upstream raw materials:

2-methyl-2-nitro-butan-1-ol

α-ethylalanine ethyl ester

2-Methyl-1-butene

DL-isovaline

Refernces

• 1、 Yendapally, Raghunandan,Lee, Richard E.. "Design, synthesis, and evaluation of novel ethambutol analogues". . p. 1607 - 1611. Retrieved 2008/12/21.
• 2、 Tang,Volkman,Ellman. "Asymmetric synthesis of protected 1,2-amino alcohols using tert-butanesulfinyl aldimines and ketimines". . p. 8772 - 8778. Retrieved 2007/10/03.