2-Nitro-3-amino-5-p-tolylthiophene

Base Information

Chemical Name:2-Nitro-3-amino-5-p-tolylthiophene
CAS No.:1021443-92-4
Molecular Formula:C11H10N2O2S
Molecular Weight:234.2743
Hs Code.:2934999090
DSSTox Substance ID:DTXSID70705252
Nikkaji Number:J2.569.776F
Wikidata:Q82638048
Mol file:1021443-92-4.mol

Synonyms:2-Nitro-3-amino-5-p-tolylthiophene;1021443-92-4;DTXSID70705252;5-(4-methylphenyl)-2-nitrothiophen-3-amine;2-Nitro-3-amino-5-(4-methylphenyl)thiophene

Suppliers and Price of 2-Nitro-3-amino-5-p-tolylthiophene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-NITRO-3-AMINO-5-P-TOLYLTHIOPHENE 95.00%
1G
$ 1273.39

Total 1 raw suppliers

Chemical Property of 2-Nitro-3-amino-5-p-tolylthiophene

Chemical Property:

PSA：100.08000
LogP:4.31830
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:234.04629874
Heavy Atom Count:16
Complexity:261

Purity/Quality:

97% ^*data from raw suppliers

2-NITRO-3-AMINO-5-P-TOLYLTHIOPHENE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2=CC(=C(S2)[N+](=O)[O-])N

Technology Process of 2-Nitro-3-amino-5-p-tolylthiophene

There total 3 articles about 2-Nitro-3-amino-5-p-tolylthiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 563-70-2
bromonitromethane

: 2-bromo-2-chloro-3-(4-methylphenyl)propanenitrile

: 1021443-92-4
3-amino-5-(4-methylphenyl)-2-nitrothiophene

Guidance literature:: bromonitromethane; With sodium hydrogen sulfide; In methanol; at -5 ℃; for 1h; Inert atmosphere;

2-bromo-2-chloro-3-(4-methylphenyl)propanenitrile; With sodium methylate; In methanol; at -5 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1002/ejoc.201901512

Reference yield: 60.0%

: 943252-37-7
(Z)-3-chloro-3-(4-methylphenyl)-2-propenenitrile

: 563-70-2
bromonitromethane

: 1021443-92-4
3-amino-5-(4-methylphenyl)-2-nitrothiophene

Guidance literature:: (Z)-3-chloro-3-(4-methylphenyl)-2-propenenitrile; With sodium sulfide; In N,N-dimethyl-formamide; at 55 ℃; for 1.5h;

bromonitromethane; In N,N-dimethyl-formamide; at 55 ℃; for 1.5h;

With sodium hydroxide; In water; N,N-dimethyl-formamide; at 55 ℃; for 0.5h; Further stages.;
DOI:10.1016/j.tet.2008.01.078

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 1021443-92-4
3-amino-5-(4-methylphenyl)-2-nitrothiophene

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen bromide; sodium nitrite / water / 0.08 h / -5 - 5 °C

1.2: 20 °C

2.1: sodium hydrogen sulfide / methanol / 1 h / -5 °C / Inert atmosphere

2.2: 4 h / -5 - 20 °C / Inert atmosphere

With sodium hydrogen sulfide; hydrogen bromide; sodium nitrite; In methanol; water; 1.2: |Meerwein Arylation;
DOI:10.1002/ejoc.201901512