PYRIDINE, 2-(4-METHOXYPHENOXY)-4-(TRIFLUOROMETHYL)-

Base Information

• Chemical Name: PYRIDINE, 2-(4-METHOXYPHENOXY)-4-(TRIFLUOROMETHYL)-
• CAS No.: 260788-74-7
• Molecular Formula: C₁₃H₁₀F₃NO₂
• Molecular Weight: 269.223
• Mol file: 260788-74-7.mol

Synonyms:PYRIDINE, 2-(4-METHOXYPHENOXY)-4-(TRIFLUOROMETHYL)-

Chemical Property of PYRIDINE, 2-(4-METHOXYPHENOXY)-4-(TRIFLUOROMETHYL)-

Chemical Property:

• Boiling Point: 330.9±42.0 °C(Predicted)
• PKA: 1.20±0.20(Predicted)
• Density: 1.277±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of PYRIDINE, 2-(4-METHOXYPHENOXY)-4-(TRIFLUOROMETHYL)-

There total 1 articles about PYRIDINE, 2-(4-METHOXYPHENOXY)-4-(TRIFLUOROMETHYL)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

triphenyl(4-(trifluoromethyl)pyridin-2-yl)phosphonium trifluoromethanesulfonate + 4-methoxy-phenol (150-76-5) → 2-(4-methoxyphenoxy)-4-(trifluoromethyl)pyridine (260788-74-7)

Guidance literature:

4-methoxy-phenol; With 15-crown-5; sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

triphenyl(4-(trifluoromethyl)pyridin-2-yl)phosphonium trifluoromethanesulfonate; In tetrahydrofuran; mineral oil; at 60 ℃; for 2h; Inert atmosphere;

DOI:10.1002/anie.201807322

upstream raw materials:

4-methoxy-phenol

Refernces