7-fluoro-3-phenyl-4H-chroMen-4-one

Base Information

• Chemical Name: 7-fluoro-3-phenyl-4H-chroMen-4-one
• CAS No.: 1186060-54-7
• Molecular Formula: C15H9FO2
• Molecular Weight: 240.2291632
• Mol file: 1186060-54-7.mol

Synonyms:7-fluoro-3-phenyl-4H-chroMen-4-one

Chemical Property of 7-fluoro-3-phenyl-4H-chroMen-4-one

Chemical Property:

• PSA: 30.21000
• LogP: 3.59910

Purity/Quality:

97-99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-fluoro-3-phenyl-4H-chroMen-4-one

There total 1 articles about 7-fluoro-3-phenyl-4H-chroMen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-bromo-7-fluoro-4H-chromen-4-one (1159978-73-0) + phenylboronic acid (98-80-6) → 7-fluoro-3-phenyl-4H-chromen-4-one (1186060-54-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In benzene; for 13h; Reflux; Inert atmosphere;

DOI:10.1021/ol901676f

Reference yield: 78.0%

2-cyanothioacetamide + 7-fluoro-3-phenyl-4H-chromen-4-one (1186060-54-7) → 3-cyano-6-(4-fluoro-2-hydroxylphenyl)-5-phenylpyridine-2(1H)-thione (1427272-72-7)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 90 ℃; for 5h;

DOI:10.1039/c3ob27247h

Reference yield: 67.0%

7-fluoro-3-phenyl-4H-chromen-4-one (1186060-54-7) → 7-fluoro-3-phenylchroman-4-one (1186060-60-5)

Guidance literature:

With L-Selectride; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol901676f

upstream raw materials:

3-bromo-7-fluoro-4H-chromen-4-one

phenylboronic acid

Downstream raw materials:

7-fluoro-3-phenylchroman-4-one

3-cyano-6-(4-fluoro-2-hydroxylphenyl)-5-phenylpyridine-2(1H)-thione

Refernces