2-aMino-4-(trifluoroMethyl)pyriMidin-5-ylboronic acid

Base Information

• Chemical Name: 2-aMino-4-(trifluoroMethyl)pyriMidin-5-ylboronic acid
• CAS No.: 1045861-30-0
• Molecular Formula: C5H5BF3N3O2
• Molecular Weight: 206.9183096
• Hs Code.: 2933599090
• Mol file: 1045861-30-0.mol

Synonyms:2-aMino-4-(trifluoroMethyl)pyriMidin-5-ylboronic acid

Chemical Property of 2-aMino-4-(trifluoroMethyl)pyriMidin-5-ylboronic acid

Chemical Property:

• PSA: 92.26000
• LogP: -0.66140
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

(2-Amino-4-(trifluoromethyl)-pyrimidin-5-yl)boronic acid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-aMino-4-(trifluoroMethyl)pyriMidin-5-ylboronic acid

There total 2 articles about 2-aMino-4-(trifluoroMethyl)pyriMidin-5-ylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-4-(trifluoromethyl)-2-pyrimidylamine (935534-47-7) → C5H5BF3N3O2 (1045861-30-0)

Guidance literature:

5-bromo-4-(trifluoromethyl)-2-pyrimidylamine; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane; In 1,4-dioxane; at 115 ℃; for 6h; Inert atmosphere;

With water; trifluoroacetic acid; In acetonitrile;

DOI:10.1021/ml200156t

Reference yield:

2-amino-4-trifluoromethylpyrimidine (16075-42-6) → C5H5BF3N3O2 (1045861-30-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / chloroform / 20 h / Darkness

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane / 1,4-dioxane / 6 h / 115 °C / Inert atmosphere

With N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane; In 1,4-dioxane; chloroform;

DOI:10.1021/ml200156t

upstream raw materials:

5-bromo-4-(trifluoromethyl)-2-pyrimidylamine

2-amino-4-trifluoromethylpyrimidine

Refernces