1H-2-Oxa-7a-azacyclopent[cd]inden-1-one, 4-ethylidene-2a,3,4,6,7,7b-hexahydro-3-hydroxy-, [2aS-(2a-alpha-,3-alpha-,4E,7b-alpha-)]- (9CI)

Base Information

Chemical Name:1H-2-Oxa-7a-azacyclopent[cd]inden-1-one, 4-ethylidene-2a,3,4,6,7,7b-hexahydro-3-hydroxy-, [2aS-(2a-alpha-,3-alpha-,4E,7b-alpha-)]- (9CI)
CAS No.:109958-09-0
Molecular Formula:C11H13NO3
Molecular Weight:207.23
Hs Code.:
Mol file:109958-09-0.mol

Synonyms:1H-2-Oxa-7a-azacyclopent[cd]inden-1-one, 4-ethylidene-2a,3,4,6,7,7b-hexahydro-3-hydroxy-, [2aS-(2a-alpha-,3-alpha-,4E,7b-alpha-)]- (9CI)

Suppliers and Price of 1H-2-Oxa-7a-azacyclopent[cd]inden-1-one, 4-ethylidene-2a,3,4,6,7,7b-hexahydro-3-hydroxy-, [2aS-(2a-alpha-,3-alpha-,4E,7b-alpha-)]- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-2-Oxa-7a-azacyclopent[cd]inden-1-one, 4-ethylidene-2a,3,4,6,7,7b-hexahydro-3-hydroxy-, [2aS-(2a-alpha-,3-alpha-,4E,7b-alpha-)]- (9CI)

Chemical Property:

PSA：49.77000
LogP:0.76460

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-2-Oxa-7a-azacyclopent[cd]inden-1-one, 4-ethylidene-2a,3,4,6,7,7b-hexahydro-3-hydroxy-, [2aS-(2a-alpha-,3-alpha-,4E,7b-alpha-)]- (9CI)

There total 9 articles about 1H-2-Oxa-7a-azacyclopent[cd]inden-1-one, 4-ethylidene-2a,3,4,6,7,7b-hexahydro-3-hydroxy-, [2aS-(2a-alpha-,3-alpha-,4E,7b-alpha-)]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109908-52-3
8-bromo-1,2-dimethoxy-1,5,6,8a-tetrahydro-3(2H)-indolizinone

: 80152-07-4,95119-34-9,95119-35-0,109958-09-0
(+)-streptazoline and its E-ethylidene isomer

Guidance literature:: Multi-step reaction with 6 steps

1: 2,6-di-tert-butylpyridine / CH₂Cl₂ / 6 h / Ambient temperature

2: acetonitrile / 0.17 h

3: 1.6 g / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

4: 66 percent / 1.4 M sec-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

5: 56 percent / 1.0 M boron tribromide / CH₂Cl₂ / 1 h / 0 °C

6: 2.) 25 percent NaOAc, 3.) 5 percent NaOMe / 1.) ether, 65 deg C, 2.) AcOH, 23 deg C, 3.) MeOH, 23 deg C

With 2,6-di-tert-butyl-pyridine; sec.-butyllithium; sodium methylate; sodium acetate; boron tribromide; triethylamine; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;
DOI:10.1021/ja00254a034

Reference yield:

: 109908-58-9
(1S,8R,9S)-2-(carboethoxy)-8,9-dimethoxy-2-azabicyclo<4.3.0>non-5-en-7-one

: 80152-07-4,95119-34-9,95119-35-0,109958-09-0
(+)-streptazoline and its E-ethylidene isomer

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / 1.0 M boron tribromide / CH₂Cl₂ / 1 h / 0 °C

2: 2.) 25 percent NaOAc, 3.) 5 percent NaOMe / 1.) ether, 65 deg C, 2.) AcOH, 23 deg C, 3.) MeOH, 23 deg C

With sodium methylate; sodium acetate; boron tribromide; In dichloromethane;
DOI:10.1021/ja00254a034

Reference yield:

: 109927-29-9
(3R,4R)-1-((E)-4-Bromo-4-trimethylsilanyl-but-3-enyl)-5-hydroxy-3,4-dimethoxy-pyrrolidin-2-one

: 80152-07-4,95119-34-9,95119-35-0,109958-09-0
(+)-streptazoline and its E-ethylidene isomer

Guidance literature:: Multi-step reaction with 7 steps

1: 1.17 g / trifluoroacetic acid / 6 h / Heating

2: 2,6-di-tert-butylpyridine / CH₂Cl₂ / 6 h / Ambient temperature

3: acetonitrile / 0.17 h

4: 1.6 g / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

5: 66 percent / 1.4 M sec-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

6: 56 percent / 1.0 M boron tribromide / CH₂Cl₂ / 1 h / 0 °C

7: 2.) 25 percent NaOAc, 3.) 5 percent NaOMe / 1.) ether, 65 deg C, 2.) AcOH, 23 deg C, 3.) MeOH, 23 deg C

With 2,6-di-tert-butyl-pyridine; sec.-butyllithium; sodium methylate; sodium acetate; boron tribromide; triethylamine; In tetrahydrofuran; hexane; dichloromethane; acetonitrile; trifluoroacetic acid;
DOI:10.1021/ja00254a034