TP0903

Base Information

Chemical Name:TP0903
CAS No.:1341200-45-0
Molecular Formula:C24H30ClN7O2S
Molecular Weight:516.067
Hs Code.:
Mol file:1341200-45-0.mol

Synonyms:TP0903;TP-0903;2-[[5-Chloro-2-[[4-[(4-methyl-1-piperazinyl)methyl]phenyl]amino]-4-pyrimidinyl]amino]-N,N-dimethylbenzenesulfonamide

Suppliers and Price of TP0903

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
TP-0903
2.5mg
$ 55.00

TRC
TP-0903
25mg
$ 450.00

DC Chemicals
TP-0903 >98%
100 mg
$ 550.00

DC Chemicals
TP-0903 >98%
250 mg
$ 1000.00

DC Chemicals
TP-0903 >98%
1 g
$ 1900.00

Crysdot
TP-0903 98+%
100mg
$ 1130.00

Crysdot
TP-0903 98+%
50mg
$ 681.00

ChemScene
Dubermatinib 99.82%
50mg
$ 290.00

ChemScene
Dubermatinib 99.82%
5mg
$ 70.00

ChemScene
Dubermatinib 99.82%
10mg
$ 100.00

Total 30 raw suppliers

Chemical Property of TP0903

Chemical Property:

Boiling Point:664.7±65.0 °C(Predicted)
PKA:7.60±0.10(Predicted)
PSA：102.08000
Density:1.347±0.06 g/cm3(Predicted)
LogP:4.71750
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

TP-0903 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses TP-0903 is an AXL kinase inhibitor.

Technology Process of TP0903

There total 8 articles about TP0903 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 109-01-3
1-methyl-piperazine

: 2-((5-chloro-2-((4-(chloromethyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide

: 1341200-45-0
2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide

Guidance literature:: 2-((5-chloro-2-((4-(chloromethyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide; With potassium carbonate; In acetonitrile; at 20 ℃; for 1h;

1-methyl-piperazine; In acetonitrile; at 65 ℃; for 6h;

Reference yield: 62.0%

: 1022956-26-8
2-((2,5-dichloropyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide

: 70261-82-4
4-[(4-methyl-1-piperazinyl)methyl]aniline

: 1341200-45-0
2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tert-butyl alcohol; for 12h; Reflux;
DOI:10.1021/ml200198x

Reference yield:

: 54468-86-9
2-amino-N,N-dimethyl-benzenesulfonamide

: 1341200-45-0
2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate / 4 h / 90 °C

2.1: tetra(n-butyl)ammonium hydrogensulfate / 12 h / 110 °C

3.1: borane-THF / tetrahydrofuran / 12 h / 0 °C

3.2: 4 h / 0 - 20 °C

4.1: thionyl chloride / dichloromethane / 4 h / Reflux

5.1: potassium carbonate / acetonitrile / 7 h / 20 - 65 °C

With thionyl chloride; borane-THF; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In tetrahydrofuran; dichloromethane; acetonitrile;