L 35

Base Information

• Chemical Name: L 35
• CAS No.: 121809-80-1
• Molecular Formula: C17H16 Cl2 N2 O4
• Molecular Weight: 383.23
• Mol file: 121809-80-1.mol

Synonyms:L 35; L 35(pharmaceutical)

Chemical Property of L 35

Chemical Property:

• Vapor Pressure: 4.21E-09mmHg at 25°C
• Boiling Point: 455.9°Cat760mmHg
• Flash Point: 229.5°C
• PSA: 91.15000
• Density: 1.462g/cm³
• LogP: 4.96600
• Storage Temp.: -196°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L 35

There total 6 articles about L 35 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-(4-aminophenoxy)-2-methyl propionic acid (117011-70-8) + 3,4-dichlorophenyl isocyanate (34893-92-0) → 2-<4<<<(3,5-dichlorophenyl)amino>carbonyl>amino>phenoxy>-2-methylpropionic acid (121809-80-1)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; a) ice-salt-bath, 0.5 h, b) 1 h;

DOI:10.1021/jm00130a021

Reference yield:

(4-hydroxyphenyl)carbamic acid ethyl ester (7159-95-7) → 2-<4<<<(3,5-dichlorophenyl)amino>carbonyl>amino>phenoxy>-2-methylpropionic acid (121809-80-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 48 percent / NaOH / 4 h / Heating

2: 87 percent / 10percent KOH / 0.5 h / Heating

3: 88 percent / 2 N NaOH / tetrahydrofuran / a) ice-salt-bath, 0.5 h, b) 1 h

With potassium hydroxide; sodium hydroxide; In tetrahydrofuran;

DOI:10.1021/jm00130a021

Reference yield:

4-cyanophenol (767-00-0) → 2-<4<<<(3,5-dichlorophenyl)amino>carbonyl>amino>phenoxy>-2-methylpropionic acid (121809-80-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 78 percent / NaOH / a) 20 min, b) reflux, 4 h

2: 88 percent / 3percent H₂O₂, KOH / H₂O

3: 90 percent / Br₂, NaOH / H₂O / 0.5 h / 75 °C

4: 88 percent / 2 N NaOH / tetrahydrofuran / a) ice-salt-bath, 0.5 h, b) 1 h

With potassium hydroxide; sodium hydroxide; dihydrogen peroxide; bromine; In tetrahydrofuran; water;

DOI:10.1021/jm00130a021

upstream raw materials:

2-(4-aminophenoxy)-2-methyl propionic acid

3,4-dichlorophenyl isocyanate

(4-hydroxyphenyl)carbamic acid ethyl ester

4-cyanophenol

Downstream raw materials:

C₂₃H₂₅Cl₂N₃O₇

C₁₉H₁₉Cl₂N₃O₅

Refernces