5-tert-butyl 3-ethyl 2-amino-6,7-dihydrothieno[3,2-c]pyridine-3,5(4H)-dicarboxylate

Base Information

• Chemical Name: 5-tert-butyl 3-ethyl 2-amino-6,7-dihydrothieno[3,2-c]pyridine-3,5(4H)-dicarboxylate
• CAS No.: 1101856-88-5
• Molecular Formula: C15H22N2O4S
• Molecular Weight: 326.41
• Mol file: 1101856-88-5.mol

Synonyms:5-tert-butyl 3-ethyl 2-amino-6,7-dihydrothieno[3,2-c]pyridine-3,5(4H)-dicarboxylate

Chemical Property of 5-tert-butyl 3-ethyl 2-amino-6,7-dihydrothieno[3,2-c]pyridine-3,5(4H)-dicarboxylate

Chemical Property:

• Boiling Point: 492.5±45.0 °C(Predicted)
• PKA: 0.13±0.20(Predicted)
• PSA: 110.10000
• Density: 1.252±0.06 g/cm3(Predicted)
• LogP: 3.31930

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl2-amino-5-Boc-6,7-dihydro-4H-thieno-[3,2-c]pyridine-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-tert-butyl 3-ethyl 2-amino-6,7-dihydrothieno[3,2-c]pyridine-3,5(4H)-dicarboxylate

There total 2 articles about 5-tert-butyl 3-ethyl 2-amino-6,7-dihydrothieno[3,2-c]pyridine-3,5(4H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

3-oxo-piperidine-1-carboxylic acid tert-butyl ester (98977-36-7) + ethyl 2-cyanoacetate (105-56-6) → O5-tert-butyl O3-ethyl 2-amino-6,7-dihydro-4H-thieno[3,2-c]pyridine-3,5-dicarboxylate (1101856-88-5)

Guidance literature:

With sulfur; triethylamine; In ethanol; at -5 - 20 ℃; for 20h;

Reference yield:

3-oxo-piperidine-1-carboxylic acid tert-butyl ester (98977-36-7) + ethyl 2-cyanoacetate (105-56-6) → O7-tert-butyl O3-ethyl 2-amino-5,6-dihydro-4H-thieno[2,3-b]pyridine-3,7-dicarboxylate (1101857-21-9) + O5-tert-butyl O3-ethyl 2-amino-6,7-dihydro-4H-thieno[3,2-c]pyridine-3,5-dicarboxylate (1101856-88-5)

Guidance literature:

With morpholine; sulfur; In ethanol; at 20 - 50 ℃; for 40h;

Reference yield: 85.0%

O5-tert-butyl O3-ethyl 2-amino-6,7-dihydro-4H-thieno[3,2-c]pyridine-3,5-dicarboxylate (1101856-88-5) + p-toluenesulfonyl chloride (98-59-9) → 5-(tert-butyl) 3-ethyl 2-((4-methylphenyl)sulfonamido)-6,7-dihydrothieno[3,2-c]pyridine-3,5(4H)-dicarboxylate

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃;

DOI:10.1002/anie.201806659

upstream raw materials:

3-oxo-piperidine-1-carboxylic acid tert-butyl ester

ethyl 2-cyanoacetate

Downstream raw materials:

5-tert-butyl 3-ethyl 6,7-dihydrothieno[3,2-c]pyridine-3,5(4H)-dicarboxylate

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