4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine

Base Information

Chemical Name:4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine
CAS No.:1357476-67-5
Molecular Formula:C9H9BrF3N
Molecular Weight:268.076
Hs Code.:
Mol file:1357476-67-5.mol

Synonyms:4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine;4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl);Pyridine, 4-bromo-2-(2,2,2-trifluoro-1,1-dimethylethyl)-

Suppliers and Price of 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine
50mg
$ 220.00

TRC
4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine
10mg
$ 65.00

Matrix Scientific
4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine 97%
1g
$ 3232.00

Matrix Scientific
4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine 97%
250mg
$ 1072.00

Crysdot
4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine 95+%
1g
$ 757.00

Chemenu
4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine 95%
1g
$ 716.00

Alichem
4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine
1g
$ 798.00

Total 22 raw suppliers

Chemical Property of 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine

Chemical Property:

Boiling Point:209.3±40.0 °C(Predicted)
PKA:2.29±0.10(Predicted)
PSA：12.89000
Density:1.473±0.06 g/cm3(Predicted)
LogP:3.68400
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine

There total 7 articles about 4-broMo-2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 908267-63-0
4-bromo-2-isopropylpyridine

: 2,8-difluoro-S-(trifluoromethyl)dibenzothiophenium tetrafluoroborate

: 1357476-67-5
4-bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine

Guidance literature:: 4-bromo-2-isopropylpyridine; With potassium tert-butylate; In N,N-dimethyl-formamide; for 0.5h; Inert atmosphere; Cooling with ice;

2,8-difluoro-S-(trifluoromethyl)dibenzothiophenium tetrafluoroborate; In N,N-dimethyl-formamide; at -78 - 20 ℃; for 1.5h; Temperature; Reagent/catalyst;

Reference yield: 67.37%

: 1357476-66-4
2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4(1H)-one

: 1357476-67-5
4-bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine

Guidance literature:: With phosphorus(V) oxybromide; In 1,2-dichloro-ethane; at 80 ℃; for 7h;

Reference yield:

: 889940-13-0
3,3,3-trifluoro-2,2-dimethylpropanoic acid

: 1357476-67-5
4-bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / chloroform / 4 h / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 2.5 h / -78 - 20 °C

2.3: -10 - 20 °C

3.1: ammonia / water / 1 h / 65 °C

4.1: phosphorus(V) oxybromide / 1,2-dichloro-ethane / 1 h / 85 °C

With oxalyl dichloride; ammonia; lithium hexamethyldisilazane; phosphorus(V) oxybromide; In tetrahydrofuran; chloroform; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2013.05.007