Tert-butyl 4-(3-hydroxybenzylidene)piperidine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 4-(3-hydroxybenzylidene)piperidine-1-carboxylate
CAS No.:1020329-87-6
Molecular Formula:C₁₇H₂₃NO₃
Molecular Weight:289.375
Hs Code.:
DSSTox Substance ID:DTXSID101150566
Mol file:1020329-87-6.mol

Synonyms:tert-butyl 4-(3-hydroxybenzylidene)piperidine-1-carboxylate;1020329-87-6;SCHEMBL1009267;MNSYEWZEZPNKJN-UHFFFAOYSA-N;DTXSID101150566;BP-11747;FT-0709164;tert-butyl4-(3-hydroxybenzylidene)piperidine-1-carboxylate;tert-butyl 4-[(3-hydroxyphenyl)methylidene]piperidine-1-carboxylate;1,1-Dimethylethyl 4-[(3-hydroxyphenyl)methylene]-1-piperidinecarboxylate

Suppliers and Price of Tert-butyl 4-(3-hydroxybenzylidene)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of Tert-butyl 4-(3-hydroxybenzylidene)piperidine-1-carboxylate

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:289.16779360
Heavy Atom Count:21
Complexity:387

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(=CC2=CC(=CC=C2)O)CC1

Technology Process of Tert-butyl 4-(3-hydroxybenzylidene)piperidine-1-carboxylate

There total 3 articles about Tert-butyl 4-(3-hydroxybenzylidene)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1020329-80-9
tert-butyl 4-(bromomethylidene)piperidine-1-carboxylate

: 87199-18-6
3-hydroxyphenylboronic acid

: 1020329-87-6
tert-butyl 4-(3-hydroxybenzylidene)piperidine-1-carboxylate

Guidance literature:: With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; at 50 ℃; for 1.5h;

Reference yield:

: 305794-65-4
tert-butyl 4-(dibromomethylidene)piperidine-1-carboxylate

: 1020329-87-6
tert-butyl 4-(3-hydroxybenzylidene)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; ammonium chloride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 2.5 h / 20 °C

2.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 1.5 h / 50 °C / Inert atmosphere

With methanol; potassium phosphate; ammonium chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1020329-87-6
tert-butyl 4-(3-hydroxybenzylidene)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine / dichloromethane / 0 - 20 °C

1.2: -78 - 20 °C

2.1: methanol; ammonium chloride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 2.5 h / 20 °C

3.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 1.5 h / 50 °C / Inert atmosphere

With methanol; potassium phosphate; ammonium chloride; triphenylphosphine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dichloromethane; water;