4-Hydroxy-4-(3-methylsulfanylphenyl)-piperidin-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-Hydroxy-4-(3-methylsulfanylphenyl)-piperidin-1-carboxylic acid tert-butyl ester
CAS No.:346688-66-2
Molecular Formula:C17H25NO3S
Molecular Weight:323.456
Hs Code.:
DSSTox Substance ID:DTXSID20514452
Wikidata:Q82374791
Mol file:346688-66-2.mol

Synonyms:346688-66-2;4-HYDROXY-4-(3-METHYLSULFANYLPHENYL)-PIPERIDIN-1-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-butyl 4-hydroxy-4-(3-methylsulfanylphenyl)piperidine-1-carboxylate;MPCBFZJWRUFXRZ-UHFFFAOYSA-N;SCHEMBL4820978;DTXSID20514452;4-Hydroxy-4-(3-methylsulfanylphenyl)-piperidin-1-carboxylic Acid tBu Ester;FT-0669848;tert-Butyl 4-hydroxy-4-[3-(methylsulfanyl)phenyl]piperidine-1-carboxylate;4-hydroxy-4-(3-methylsulfanyl-phenyl)-piperidin-1-carboxylic acid tert-butyl ester

Suppliers and Price of 4-Hydroxy-4-(3-methylsulfanylphenyl)-piperidin-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
4-Hydroxy-4-(3-methylsulfanylphenyl)-piperidin-1-carboxylicAcidtert-ButylEster
5 g
$ 2000.00

Total 1 raw suppliers

Chemical Property of 4-Hydroxy-4-(3-methylsulfanylphenyl)-piperidin-1-carboxylic acid tert-butyl ester

Chemical Property:

Melting Point:110-112°C
PSA：75.07000
LogP:3.56490
Storage Temp.:-20°C Freezer
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:323.15551483
Heavy Atom Count:22
Complexity:386

Purity/Quality:: 4-Hydroxy-4-(3-methylsulfanylphenyl)-piperidin-1-carboxylicAcidtert-ButylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)(C2=CC(=CC=C2)SC)O

Technology Process of 4-Hydroxy-4-(3-methylsulfanylphenyl)-piperidin-1-carboxylic acid tert-butyl ester

There total 2 articles about 4-Hydroxy-4-(3-methylsulfanylphenyl)-piperidin-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 346688-66-2
1-tert-butoxycarbonyl-4-hydroxy-4-[3-(methylthio)phenyl]piperidine

Guidance literature:: 3-bromo-1-(methylthio)benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 0.583333h;

N-tert-butyloxycarbonylpiperidin-4-one; In tetrahydrofuran; hexane; at 20 ℃; for 1h;

With ammonium chloride; In tetrahydrofuran; hexane;

Reference yield: 72.0%

: 33733-73-2
3-bromo-1-(methylthio)benzene

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 346688-66-2
1-tert-butoxycarbonyl-4-hydroxy-4-[3-(methylthio)phenyl]piperidine

Guidance literature:: 3-bromo-1-(methylthio)benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -20 ℃; for 0.533333h; Inert atmosphere;

N-tert-butyloxycarbonylpiperidin-4-one; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; hexane; water;
DOI:10.1021/jm901689v