ETHYL 5-[(3R)-3,4-DIHYDROXYBUTYL]THIOPHENE-2-CARBOXYLATE

Base Information

Chemical Name:ETHYL 5-[(3R)-3,4-DIHYDROXYBUTYL]THIOPHENE-2-CARBOXYLATE
CAS No.:208337-83-1
Molecular Formula:C₁₁H₁₆O₄S
Molecular Weight:244.312
Hs Code.:
Mol file:208337-83-1.mol

Synonyms:ETHYL 5-[(3R)-3,4-DIHYDROXYBUTYL]THIOPHENE-2-CARBOXYLATE;5-[(3R)-3,4-Dihydroxybutyl]-2-thiophenecarboxylic acid ethyl ester

Suppliers and Price of ETHYL 5-[(3R)-3,4-DIHYDROXYBUTYL]THIOPHENE-2-CARBOXYLATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of ETHYL 5-[(3R)-3,4-DIHYDROXYBUTYL]THIOPHENE-2-CARBOXYLATE

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of ETHYL 5-[(3R)-3,4-DIHYDROXYBUTYL]THIOPHENE-2-CARBOXYLATE

There total 3 articles about ETHYL 5-[(3R)-3,4-DIHYDROXYBUTYL]THIOPHENE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 186521-21-1
5-[2-(2,2-dimethyl-[1,3]-dioxolan-4(S)-yl)-ethyl]-thiophene-2-carboxylic acid ethyl ester

: 186521-22-2,208337-83-1
5-(3(S)-4-dihydroxy-butyl)-thiophene-2-carboxylic acid ethyl ester

Guidance literature:: With ethanol; toluene-4-sulfonic acid; at 65 ℃; for 3h;
DOI:10.1021/jm9607459

Reference yield:

: 5751-83-7
ethyl 5-bromothiophene-2-carboxylate

: 186521-22-2,208337-83-1
5-(3(S)-4-dihydroxy-butyl)-thiophene-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: CuI, (Ph₃P)2PdCl₂ / diethylamine / Ambient temperature

2: H₂ / 5percent Pd-C / ethanol / 3.5 h / 2327.2 Torr

3: 98 percent / p-toluenesulfonic acid monohydrate, EtOH / 3 h / 65 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ethanol; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In ethanol; diethylamine;
DOI:10.1021/jm9607459

Reference yield:

: 186521-20-0
5-(2,2-dimethyl-[1,3]dioxolan-4(S)-yl-ethynyl)-thiophene-2-carboxylic acid ethyl ester

: 186521-22-2,208337-83-1
5-(3(S)-4-dihydroxy-butyl)-thiophene-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 5percent Pd-C / ethanol / 3.5 h / 2327.2 Torr

2: 98 percent / p-toluenesulfonic acid monohydrate, EtOH / 3 h / 65 °C

With ethanol; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm9607459