LEE011 (hydrochloride)

Base Information

• Chemical Name: LEE011 (hydrochloride)
• CAS No.: 1211443-80-9
• Molecular Formula: C23H30N8O.HCl
• Molecular Weight: 470.99824
• Mol file: 1211443-80-9.mol

Synonyms:LEE011 (hydrochloride);7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride (1:1);LEE-011 HCl salt, Ribociclib HCl salt;Ribociclib (Hydrochloride)

Chemical Property of LEE011 (hydrochloride)

Chemical Property:

• PSA: 91.21000
• LogP: 4.06520

Purity/Quality:

98% ^*data from raw suppliers

LEE011hydrochloride >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of LEE011 (hydrochloride)

There total 1 articles about LEE011 (hydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(7-cyclopentyl-Ν,Ν-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo [2,3-d]pyrimidine-6-carboxamide) (1211441-98-3) → 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide hydrochloride (1211443-80-9)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 2h;

upstream raw materials:

(7-cyclopentyl-Ν,Ν-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo [2,3-d]pyrimidine-6-carboxamide)

Refernces