cis-3-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]cyclobutaneMethanol

Base Information

• Chemical Name: cis-3-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]cyclobutaneMethanol
• CAS No.: 959749-93-0
• Molecular Formula: C11H24O2Si
• Molecular Weight: 216.396
• Mol file: 959749-93-0.mol

Synonyms:cis-3-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]cyclobutaneMethanol;(cis-3-((tert-Butyldimethylsilyl)oxy)cyclobutyl)methanol

Chemical Property of cis-3-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]cyclobutaneMethanol

Chemical Property:

• PSA: 29.46000
• LogP: 2.77910
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99%, ^*data from raw suppliers

cis-3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]cyclobutanemethanol 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of cis-3-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]cyclobutaneMethanol

There total 4 articles about cis-3-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]cyclobutaneMethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(cis-3-(benzyloxymethyl)cyclobutoxy)(tert-butyl)dimethylsilane (959749-92-9) → ((1s,3s)-3-((((tert-butyl)dimethyl)silyl)oxy)cyclobutyl)methanol (959749-93-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 72h; under 760.051 Torr;

Reference yield:

cis-methyl 3-(tert-butyldimethylsilyloxy)cyclobutanecarboxylate → ((1s,3s)-3-((((tert-butyl)dimethyl)silyl)oxy)cyclobutyl)methanol (959749-93-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 2h;

Reference yield:

cis-3-hydroxycyclobutylcarboxylic acid methyl ester (63485-50-7) → ((1s,3s)-3-((((tert-butyl)dimethyl)silyl)oxy)cyclobutyl)methanol (959749-93-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-imidazole / dichloromethane / 12 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; dichloromethane;

upstream raw materials:

(cis-3-(benzyloxymethyl)cyclobutoxy)(tert-butyl)dimethylsilane

cis-3-hydroxycyclobutylcarboxylic acid methyl ester

methyl 3-oxocyclobutanecarboxylate

Downstream raw materials:

2-[(cis-3-{[tert-butyl(dimethyl)silyl]oxy}cyclobutyl)methoxy]-N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-(trifluoromethyl)benzamide

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