Ethyl 3-(4-chlorophenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate

Base Information

Chemical Name:Ethyl 3-(4-chlorophenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate
CAS No.:173678-19-8
Molecular Formula:C16H14ClN3O2
Molecular Weight:315.75
Hs Code.:
DSSTox Substance ID:DTXSID601149843
ChEMBL ID:CHEMBL1331001

Synonyms:ethyl 3-(4-chlorophenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate;173678-19-8;Enamine_003322;MLS000708723;CHEMBL1331001;DTXSID601149843;HMS1403G22;HMS2620N19;STK191715;AKOS000550661;SMR000289290;CS-0298832;Z56849128;ethyl3-(4-chlorophenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate

Suppliers and Price of Ethyl 3-(4-chlorophenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
ethyl3-(4-chlorophenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate 95%
1g
$ 745.00

Total 3 raw suppliers

Chemical Property of Ethyl 3-(4-chlorophenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate

Chemical Property:

PSA：56.49000
LogP:3.53480
XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:315.0774544
Heavy Atom Count:22
Complexity:401

Purity/Quality:

99% ^*data from raw suppliers

ethyl3-(4-chlorophenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(N2C(=C(C=N2)C3=CC=C(C=C3)Cl)N=C1)C

Technology Process of Ethyl 3-(4-chlorophenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate

There total 3 articles about Ethyl 3-(4-chlorophenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 57999-09-4
5-amino-4-(4-chlorophenyl)-1Н-pyrazole

: 3788-94-1
2-ethoxymethylene-3-oxobutanoic acid ethyl ester

: 173678-19-8
Ethyl 3-(4-chlorophenyl)-7-methylpyrazolo<1,5-a>pyrimidin-6-carboxylate

Guidance literature:: In ethanol; for 0.5h; Heating;

Reference yield:

: 62538-21-0
2-(4-chloro-phenyl)-3-oxo-propionitrile

: 173678-19-8
Ethyl 3-(4-chlorophenyl)-7-methylpyrazolo<1,5-a>pyrimidin-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / hydrazine hydrate, acetic acid / ethanol / 6 h / Heating

2: 73 percent / ethanol / 0.5 h / Heating

With hydrazine hydrate; acetic acid; In ethanol;

Reference yield:

: 140-53-4
p-chlorobenzyl cyanide

: 173678-19-8
Ethyl 3-(4-chlorophenyl)-7-methylpyrazolo<1,5-a>pyrimidin-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / NaH, tert. amyl alcohol / toluene / 6 h / 70 - 80 °C

2: 81 percent / hydrazine hydrate, acetic acid / ethanol / 6 h / Heating

3: 73 percent / ethanol / 0.5 h / Heating

With tert-Amyl alcohol; sodium hydride; hydrazine hydrate; acetic acid; In ethanol; toluene;