H57Reu3dhp

Base Information

Chemical Name:H57Reu3dhp
CAS No.:315706-13-9
Molecular Formula:C18H12Cl2N4O4S
Molecular Weight:451.29
Hs Code.:
UNII:H57REU3DHP
Wikipedia:4EGI-1
ChEMBL ID:CHEMBL254578
Mol file:315706-13-9.mol

Synonyms:4egi-1;315706-13-9;H57REU3DHP;(Z)-4EGI-1;UNII-H57REU3DHP;CHEMBL254578;alpha-(2-(4-(3,4-Dichlorophenyl)-2-thiazolyl)hydrazinylidene)-2-nitrobenzenepropanoic acid;Benzenepropanoic acid, alpha-((4-(3,4-dichlorophenyl)-2-thiazolyl)hydrazono)-2-nitro-;4EGI1;4EGI 1;SCHEMBL3334288;(2e)-2-{2-[4-(3,4-Dichlorophenyl)-1,3-Thiazol-2-Yl]hydrazinylidene}-3-(2-Nitrophenyl)propanoic Acid;2-((4-(3,4-dichlorophenyl)thiazol-2(3H)-ylidene)hydrazono)-3-(2-nitrophenyl)propanoic acid;BCP28021;BDBM50018919;AKOS016372526;AKOS040755630;Q27453517;4 EGI1;4-EGI1;4 EGI 1;4-EGI-1;.ALPHA.-(2-(4-(3,4-DICHLOROPHENYL)-2-THIAZOLYL)HYDRAZINYLIDENE)-2-NITROBENZENEPROPANOIC ACID;BENZENEPROPANOIC ACID, .ALPHA.-((4-(3,4-DICHLOROPHENYL)-2-THIAZOLYL)HYDRAZONO)-2-NITRO-

Suppliers and Price of H57Reu3dhp

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1
10mg
$ 516.00

TRC
eIF4E/eIF4GInteractionInhibitor,4EGI-1
10mg
$ 210.00

DC Chemicals
4EGI-1 >98%
1 g
$ 1900.00

DC Chemicals
4EGI-1 >98%
250 mg
$ 1000.00

Crysdot
4EGI-1 98+%
100mg
$ 406.00

Crysdot
4EGI-1 98+%
10mg
$ 91.00

Crysdot
4EGI-1 98+%
5mg
$ 69.00

Crysdot
4EGI-1 98+%
25mg
$ 168.00

Crysdot
4EGI-1 98+%
50mg
$ 245.00

ChemScene
4EGI-1 98.83%
25mg
$ 264.00

Total 19 raw suppliers

Chemical Property of H57Reu3dhp

Chemical Property:

Boiling Point:668.9±65.0 °C(Predicted)
PKA:0.89±0.41(Predicted)
PSA：143.05000
Density:1.58±0.1 g/cm3(Predicted)
LogP:3.82150
Solubility.:≥22.56 mg/mL in DMSO
XLogP3:6.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:449.9956314
Heavy Atom Count:29
Complexity:636

Purity/Quality:

98% ^*data from raw suppliers

eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)CC(=NNC2=NC(=CS2)C3=CC(=C(C=C3)Cl)Cl)C(=O)O)[N+](=O)[O-]
Isomeric SMILES:C1=CC=C(C(=C1)C/C(=N/NC2=NC(=CS2)C3=CC(=C(C=C3)Cl)Cl)/C(=O)O)[N+](=O)[O-]
Description In eukaryotes, a set of initiation factors (eIFs) interact with ribosomal subunits to initiate mRNA translation. A major step in initiation is the assembly of a large multiprotein complex that includes the cap-binding protein eIF4E and the multidomain adaptor protein eIF4G. 4EGI-1 is an inhibitor of the initiation of translation that blocks the interaction of eIF4G with eIF4E (KD = 25 μM). It directly binds eIF4E, competitively inhibiting an association with eIF4G that is necessary for cap-dependent translation. 4EGI-1 prevents the expression of oncogenic proteins in mammalian cancer cells, leading to apoptosis. Research with this inhibitor supports a role for normal eIF4E/eIF4G interaction in memory consolidation and excess interaction in autism spectrum disorders. 4EGI-1 also blocks translation in some viruses that do not require eIF4E or a cap structure for initiation.
Uses eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 is amplifies TRAIL-induced apoptosis via down-regulation of FLIPS/L?and induction of DR5.

Technology Process of H57Reu3dhp

There total 1 articles about H57Reu3dhp which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.7%