tert-butyl 6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate

Base Information

• Chemical Name: tert-butyl 6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate
• CAS No.: 165894-06-4
• Molecular Formula: C11H17N3O2
• Molecular Weight: 223.27158
• Mol file: 165894-06-4.mol

Synonyms:tert-butyl 6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate;5-Boc-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine

Chemical Property of tert-butyl 6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate

Chemical Property:

• Boiling Point: 350.4±35.0 °C(Predicted)
• PKA: 2.29±0.20(Predicted)
• PSA: 47.36000
• Density: 1.20±0.1 g/cm3(Predicted)
• LogP: 1.57170

Purity/Quality:

99%, ^*data from raw suppliers

tert-butyl6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate ^*data from reagent suppliers

Safty Information:

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Technology Process of tert-butyl 6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate

There total 10 articles about tert-butyl 6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + 5-benzyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine → 6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxylic acid tert-butyl ester (165894-06-4)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; for 6h;

DOI:10.1021/ml500353p

Reference yield: 88.0%

di-tert-butyl dicarbonate (24424-99-5) + C14H17N3 → 6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxylic acid tert-butyl ester (165894-06-4)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; for 6h;

DOI:10.1021/ml500353p

Reference yield:

2-[tert-butoxycarbonyl(1H-pyrazol-5-ylmethyl)amino]ethyl methanesulfonate → 6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxylic acid tert-butyl ester (165894-06-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h;

upstream raw materials:

di-tert-butyl dicarbonate

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