4-CHLORO-8-METHOXY-2-(TRIFLUOROMETHYL)QUINOLINE

Base Information

• Chemical Name: 4-CHLORO-8-METHOXY-2-(TRIFLUOROMETHYL)QUINOLINE
• CAS No.: 41192-89-6
• Molecular Formula: C₁₁H₇ClF₃NO
• Molecular Weight: 261.631
• Hs Code.: 2933499090
• Mol file: 41192-89-6.mol

Synonyms:4-CHLORO-8-METHOXY-2-(TRIFLUOROMETHYL)QUINOLINE;4-Chloro-2-(trifluoromethyl)quinolin-8-yl methyl ether, 4-Chloro-8-methoxy-2-(trifluoromethyl)-1-azanaphthalene;4-Chloro-8-methoxy-2-(trifluoromethyl)quinoline97%

Chemical Property of 4-CHLORO-8-METHOXY-2-(TRIFLUOROMETHYL)QUINOLINE

Chemical Property:

• Vapor Pressure: 0.00633mmHg at 25°C
• Boiling Point: 280.7°C at 760 mmHg
• Flash Point: 123.6°C
• PSA: 22.12000
• Density: 1.404g/cm³
• LogP: 3.91560
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-8-methoxy-2-(trifluoromethyl)quinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-8-METHOXY-2-(TRIFLUOROMETHYL)QUINOLINE

There total 4 articles about 4-CHLORO-8-METHOXY-2-(TRIFLUOROMETHYL)QUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-Methoxy-2-trifluoromethylquinolin-4-one (474125-09-2,41192-84-1) → 4-chloro-8-methoxy-2-trifluoromethyl-quinoline (41192-89-6)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate;

DOI:10.1016/S0960-894X(02)00224-X

Reference yield:

8-methoxy-2-trifluoromethyl-1H-quinolin-4-one (41192-84-1) → 4-chloro-8-methoxy-2-trifluoromethyl-quinoline (41192-89-6)

Guidance literature:

With trichlorophosphate; In ethanol;

Reference yield:

2-methoxy-phenylamine (90-04-0) → 4-chloro-8-methoxy-2-trifluoromethyl-quinoline (41192-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1: polyphosphoric acid

2: PCl₅; POCl₃

With PPA; phosphorus pentachloride; trichlorophosphate;

DOI:10.1016/S0960-894X(02)00224-X

upstream raw materials:

8-Methoxy-2-trifluoromethylquinolin-4-one

2-methoxy-phenylamine

8-methoxy-2-trifluoromethyl-1H-quinolin-4-one

Downstream raw materials:

8-Methoxy-2-(trifluoromethyl)quinoline-5-carboxylic acid

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