1-(4-AMINOPHENYL)-N,N-DIMETHYL-3-PYRROLIDINAMINE

Base Information

• Chemical Name: 1-(4-AMINOPHENYL)-N,N-DIMETHYL-3-PYRROLIDINAMINE
• CAS No.: 686709-51-3
• Molecular Formula: C12H19N3
• Molecular Weight: 205.303
• Mol file: 686709-51-3.mol

Synonyms:1-(4-AMINOPHENYL)-N,N-DIMETHYL-3-PYRROLIDINAMINE;1-(4-aminophenyl)-N,N-dimethylpyrrolidin-3-amine

Chemical Property of 1-(4-AMINOPHENYL)-N,N-DIMETHYL-3-PYRROLIDINAMINE

Chemical Property:

• Boiling Point: 367.8±37.0 °C(Predicted)
• PKA: 9.36±0.20(Predicted)
• PSA: 32.50000
• Density: 1.09±0.1 g/cm3(Predicted)
• LogP: 2.05530

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-AMINOPHENYL)-N,N-DIMETHYL-3-PYRROLIDINAMINE

There total 5 articles about 1-(4-AMINOPHENYL)-N,N-DIMETHYL-3-PYRROLIDINAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 1-(4-aminophenyl)-N,N-dimethylpyrrolidin-3-amine (686709-51-3)

Guidance literature:

Reference yield: 97.0%

[1-(4-nitrophenyl)-pyrrolidin-3-yl] dimethylamine (361346-46-5) → 1-(4-aminophenyl)-N,N-dimethylpyrrolidin-3-amine (686709-51-3)

Guidance literature:

With sodium dithionite; In tetrahydrofuran; for 0.5h;

DOI:10.1016/j.bmcl.2005.05.130

Reference yield:

dimethyl-pyrrolidin-3-yl-amine (69478-75-7,108138-38-1,132883-44-4,132958-72-6) + 4-Fluoronitrobenzene (350-46-9,178603-76-4) → 1-(4-aminophenyl)-N,N-dimethylpyrrolidin-3-amine (686709-51-3)

Guidance literature:

upstream raw materials:

[1-(4-nitrophenyl)-pyrrolidin-3-yl] dimethylamine

dimethyl-pyrrolidin-3-yl-amine

4-Fluoronitrobenzene

Downstream raw materials:

6-chloro-N-[4-(3-dimethylamino-pyrrolidin-1-yl)-phenyl]-nicotinamide

5-Chloropyridine-2-carboxylic acid [4-(3-dimethylaminopyrrolidin-1-yl)phenyl]amide

N-[4-(3-dimethylaminopyrrolidin-1-yl)phenyl]-6-hydroxynicotinamide

piperidine-4-carboxylic acid [4-(3-dimethylamino-pyrrolidin-1-yl)-phenyl]-amide

Refernces

• 1、 -. "IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION". Page/Page column 245. . Retrieved 2011/05/11.
• 2、 Huang, Charles Q.,Baker, Tracy,Schwarz, David,Fan, Jun,Heise, Christopher E.,Zhang, Mingzhu,Goodfellow, Val S.,Markison, Stacy,Gogas, Kathleen R.,Chen, Takung,Wang, Xiao-Chuan,Zhu, Yun-Fei. "1-(4-Amino-phenyl)-pyrrolidin-3-yl-amine and 6-(3-amino-pyrrolidin-1-yl)- pyridin-3-yl-amine derivatives as melanin-concentrating hormone receptor-1 antagonists". . p. 3701 - 3706. Retrieved 2007/10/03.