Ethylisopropylamiloride

Base Information

• Chemical Name: Ethylisopropylamiloride
• CAS No.: 1154-25-2
• Molecular Formula: C₁₁H₁₈ClN₇O
• Molecular Weight: 299.763
• Hs Code.: 2934999090
• European Community (EC) Number: 634-217-2
• UNII: VW50CE070T
• DSSTox Substance ID: DTXSID80151084
• Nikkaji Number: J240.200I
• Wikidata: Q27077241
• Pharos Ligand ID: X4A5Z4RDC2JZ
• ChEMBL ID: CHEMBL517986
• Mol file: 1154-25-2.mol

Synonyms:5-(ethylisopropyl)amiloride;5-(N-ethyl-N-isopropyl)amiloride;EIPA;ethylisopropylamiloride;N-amidino-3-amino-5-ethylisopropylamino-6-chloropyrazine carboxamide

Chemical Property of Ethylisopropylamiloride

Chemical Property:

• Appearance/Colour: Off-white to yellow solid
• Vapor Pressure: 6.83E-12mmHg at 25°C
• Melting Point: 202-205 °C(lit.)
• Refractive Index: 1.664
• Boiling Point: 543.9 °C at 760 mmHg
• PKA: 8.67±0.46(Predicted)
• Flash Point: 282.8 °C
• PSA: 134.01000
• Density: 1.49 g/cm³
• LogP: 2.34230
• Storage Temp.: 2-8°C
• Solubility.: Acetonitrile (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 299.1261359
• Heavy Atom Count: 20
• Complexity: 372

Purity/Quality:

97% ^*data from raw suppliers

EIPA ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCN(C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N)C(C)C
• Description: Sodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N-ethyl-N-isopropyl)-Amiloride (EIPA) is a potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with Ki values of 0.02, 0.5, 2.4, and 0.42 μM, respectively. It less effectively inhibits NHE4 (IC50 ≥10 μM). EIPA is commonly used at a concentration of 5-10 μM to inhibit cellular HNE activity.
• Uses: Selective Na+/H+ antiporter inhibitor. Selectively enhances the excretion of sodium ions without causing an increase in excretion of potassium ions. 5-(N-Ethyl-N-isopropyl)amiloride has been used:as a supplement in endothelial cell growth medium to incubate human lung microvascular endothelial cellin Pluronic F-127 stock solution for Drosophila larval live-imagingin choline chloride solution as an experimental perfusate, to study the effect of Na+/H+ inhibition on jejunal loop perfusion in vivo Selective Na+/H+ antiporter inhibitor. Selectively enhances the excretion of sodium ions without causing an increase in excretion of potassium ions

Technology Process of Ethylisopropylamiloride

There total 1 articles about Ethylisopropylamiloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ ethyl isopropyl amiloride (1154-25-2)

Guidance literature:

Guanidin, 2-(N-Ethyl-isopropylamino)-3-chlor-6-amino-5-methoxycarbonyl-pyrazin, abs. Me. (Siedetemp., 1min; 20grad, 1h);

DOI:10.1021/jm00313a014

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