ethyl 2-(Methylthio)-7-oxo-4,7-dihydrothiazolo[5,4-b]pyridine-6-carboxylate

Base Information

Chemical Name:ethyl 2-(Methylthio)-7-oxo-4,7-dihydrothiazolo[5,4-b]pyridine-6-carboxylate
CAS No.:91478-70-5
Molecular Formula:C₁₀H₁₀N₂O₃S₂
Molecular Weight:270.333
Hs Code.:

Synonyms:ethyl 2-(Methylthio)-7-oxo-4,7-dihydrothiazolo[5,4-b]pyridine-6-carboxylate

Suppliers and Price of ethyl 2-(Methylthio)-7-oxo-4,7-dihydrothiazolo[5,4-b]pyridine-6-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of ethyl 2-(Methylthio)-7-oxo-4,7-dihydrothiazolo[5,4-b]pyridine-6-carboxylate

Chemical Property:

Melting Point:185 °C (DMF/ethanol)
Boiling Point:402.3±55.0 °C (760 mmHg)
PSA：125.85000
Density:1.50±0.1 g/cm3 (20 °C, 760 mmHg)
LogP:2.29550

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ethyl 2-(Methylthio)-7-oxo-4,7-dihydrothiazolo[5,4-b]pyridine-6-carboxylate

There total 2 articles about ethyl 2-(Methylthio)-7-oxo-4,7-dihydrothiazolo[5,4-b]pyridine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 91478-69-2
diethyl N-<5-(2-methylthio)thiazolyl>aminomethylenemalonate

: 91478-70-5
ethyl 4-hydroxy-2-methylthiothiazolo<5,4-b>pyridine-5-carboxylate

Guidance literature:: In diphenylether; at 250 ℃; for 0.166667h;
DOI:10.1002/jhet.5570210226

Reference yield:

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 91478-70-5
ethyl 4-hydroxy-2-methylthiothiazolo<5,4-b>pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 12.5 g / ethanol / 1 h / Heating

2: 90 percent / diphenyl ether / 0.17 h / 250 °C

In diphenylether; ethanol;
DOI:10.1002/jhet.5570210226

Reference yield:

: 91478-70-5
ethyl 4-hydroxy-2-methylthiothiazolo<5,4-b>pyridine-5-carboxylate

: 91502-40-8
2-(4-Benzyl-piperazin-1-yl)-4-ethyl-7-oxo-4,7-dihydro-thiazolo[5,4-b]pyridine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 50percent NaH / 1.) DMF, 80 deg C; 2.) 80 deg C, 4 h

2: 1.) aq. 10percent NaOH; 2.) acetic acid / dimethylformamide / 1.5 h / Heating

3: 62 percent / dimethylsulfoxide / 3.5 h / 150 °C

With sodium hydroxide; sodium hydride; acetic acid; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570210226