Galanthamine-O-(methyl-d3)-N-(methyl-d3)

Base Information

• Chemical Name: Galanthamine-O-(methyl-d3)-N-(methyl-d3)
• CAS No.: 1128109-00-1
• Molecular Formula: C₁₇H₂₁NO₃
• Molecular Weight: 293.311
• Mol file: 1128109-00-1.mol

Synonyms:(4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-(methoxy-d3)-11-(methyl-d3)-6H-benzofurol[3a,3,2,-ef][2]benzazepin-6-ol;Galantamine-d6;Galanthamine-O-(methyl-d3)-N-(methyl-d3);Lycoremine-d6;(-)-GalanthaMine-d6;BRN 0093736-d6;GalantaMina-d6;GalantaMin-d6

Chemical Property of Galanthamine-O-(methyl-d3)-N-(methyl-d3)

Chemical Property:

• Melting Point: 121-122°C
• PSA: 41.93000
• LogP: 1.78820
• Storage Temp.: Hygroscopic, -20?C Freezer, Under Inert Atmosphere

Purity/Quality:

98% ^*data from raw suppliers

Galanthamine-O-(methyl-d3)-N-(methyl-d3) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: A deuterated selective acetylcholinesterase inhibitor

Technology Process of Galanthamine-O-(methyl-d3)-N-(methyl-d3)

There total 1 articles about Galanthamine-O-(methyl-d3)-N-(methyl-d3) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

paraformaldehyde-d2 (1664-98-8,43094-80-0) + 6-[2H3]methoxynorsanguinine (1128108-98-4) → (-)-6-[2H3]methoxy-N-[2H3]methyl-galanthamine (1128109-00-1,1279031-09-2)

Guidance literature:

paraformaldehyde-d2; (4aS,6R,8aS)-3-[2H₃]methoxy-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol; With deuteroacetic acid; In methanol; water; at 65 ℃; for 2h;

With sodium borodeuteride; In methanol; water; at 0 ℃; for 1h; Further stages.;

DOI:10.1002/jlcr.1510

upstream raw materials:

paraformaldehyde-d2

6-[2H3]methoxynorsanguinine

Refernces