PF-9184

Base Information

Chemical Name:PF-9184
CAS No.:1221971-47-6
Molecular Formula:C₂₁H₁₄Cl₂N₂O₄S
Molecular Weight:461.325
Hs Code.:
Mol file:1221971-47-6.mol

Synonyms:PF-9184

Suppliers and Price of PF-9184

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
PF9184
5mg
$ 85.00

Tocris
PF9184 ≥98%(HPLC)
50
$ 693.00

Tocris
PF9184 ≥98%(HPLC)
10
$ 165.00

Sigma-Aldrich
PF-03549184 ≥98% (HPLC)
5mg
$ 90.30

Sigma-Aldrich
PF-03549184 ≥98% (HPLC)
25mg
$ 364.00

Cayman Chemical
PF-9184 ≥98%
25mg
$ 263.00

Cayman Chemical
PF-9184 ≥98%
5mg
$ 88.00

Cayman Chemical
PF-9184 ≥98%
1mg
$ 35.00

Cayman Chemical
PF-9184 ≥98%
10mg
$ 123.00

ApexBio Technology
PF-9184
5mg
$ 123.00

Total 4 raw suppliers

Chemical Property of PF-9184

Chemical Property:

PSA：103.88000
LogP:6.30020
Storage Temp.:2-8°C
Solubility.:≤15mg/ml in DMSO;20mg/ml in dimethyl formamide

Purity/Quality:

98% ^*data from raw suppliers

PF9184 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Microsomal prostaglandin E synthase-1 (mPGES-1) converts the COX product prostaglandin H2 (PGH2; ) into the biologically active PGE2 . Like COX-2, the expression of mPGES-1 is induced in response to pro-inflammatory mediators, including LPS, IL-1β, and TNF-α. PF-9184 is a potent inhibitor of mPGES-1 (IC50 = 16.5 nM for recombinant human enzyme). It displays at least 6,500-fold selectivity for mPGES-1 over COX-1 and COX-2. PF-9184 blocks the synthesis of PGE2 in LPS-treated human whole blood and in IL-1β-stimulated fibroblasts (IC50s = 0.4-5 μM).
Uses PF 9184 is a?microsomal prostaglandin E?synthase-1(mPGES-1) inhibitor. mPGES-1is an enzyme induced during the inflammatory response and it is an attractive target for developing anti-inflammatory drugs.

Technology Process of PF-9184

There total 1 articles about PF-9184 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: