1-Methoxy AMiodarone

Base Information

Chemical Name:1-Methoxy AMiodarone
CAS No.:1087223-70-8
Molecular Formula:C₂₆H₃₁I₂NO₄
Molecular Weight:675.345
Hs Code.:
Mol file:1087223-70-8.mol

Synonyms:1-Methoxy AMiodarone;AMiodarone IMpurity G;[2-[(1RS)-1-Methoxybutyl]benzofuran-3-yl][4-[2-(diethylaMino)ethoxy] -3,5-diiodophenyl]Methanone;[4-[2-(DiethylaMino)ethoxy]-3,5-diiodophenyl][2-(1-Methoxybutyl)-3-benzofuranyl]Methanone;(4-(2-(diethylaMino)ethoxy)-3,5-diiodophenyl)(2-(1-Methoxybutyl)benzofuran-3-yl)Methanone;AMiodarone EP IMpurity G

Suppliers and Price of 1-Methoxy AMiodarone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-MethoxyAmiodarone
0.5mg
$ 180.00

Medical Isotopes, Inc.
1-MethoxyAmiodarone
10 mg
$ 2400.00

American Custom Chemicals Corporation
[2-[(1RS)-1-METHOXYBUTYL]BENZOFURAN-3-YL][4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODOPHENYL] METHANONE 95.00%
10MG
$ 2194.50

American Custom Chemicals Corporation
[2-[(1RS)-1-METHOXYBUTYL]BENZOFURAN-3-YL][4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODOPHENYL] METHANONE 95.00%
1MG
$ 779.63

Total 10 raw suppliers

Chemical Property of 1-Methoxy AMiodarone

Chemical Property:

Boiling Point:645.0±55.0 °C(Predicted)
PKA:9.37±0.25(Predicted)
PSA：51.91000
Density:1.563±0.06 g/cm3(Predicted)
LogP:7.08120
Storage Temp.:Amber Vial, -86°C Freezer
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

1-MethoxyAmiodarone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 1-Methoxy Amiodarone (Amiodarone EP Impurity G) is an impurity of Amiodarone (A632950). Amiodarone (A632950) impurity.

Technology Process of 1-Methoxy AMiodarone

There total 7 articles about 1-Methoxy AMiodarone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.2%

: C₁₃H₁₆ClI₂NO₂

: C₁₃H₁₅BrO₂

: 1087223-70-8
C₂₆H₃₁I₂NO₄

Guidance literature:: C₁₃H₁₅BrO₂; With n-butyllithium; In tetrahydrofuran; at -75 - -65 ℃; for 0.166667h; Inert atmosphere;

C₁₃H₁₆ClI₂NO₂; With iron(III) chloride; In tetrahydrofuran; at 25 ℃; for 2h; Temperature; Solvent; Inert atmosphere;

Reference yield:

: 3,5-Dijod-4-(2-diaethylamino-aethoxy)-benzoesaeure-methylester

: 1087223-70-8
C₂₆H₃₁I₂NO₄

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 100 °C

2.1: thionyl chloride / N,N-dimethyl-formamide; 1,2-dichloro-ethane / 3 h / 80 °C

3.1: n-butyllithium / tetrahydrofuran / 0.17 h / -75 - -65 °C / Inert atmosphere

3.2: 2 h / 25 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; thionyl chloride; In tetrahydrofuran; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 271-89-6
1-benzofurane

: 1087223-70-8
C₂₆H₃₁I₂NO₄

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -65 - -60 °C

1.2: 0.5 h / -60 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 10 - 20 °C

2.2: 0.5 h / 20 °C

3.1: N-Bromosuccinimide / dichloromethane; acetonitrile / 25 °C

4.1: n-butyllithium / tetrahydrofuran / 0.17 h / -75 - -65 °C / Inert atmosphere

4.2: 2 h / 25 °C / Inert atmosphere

With N-Bromosuccinimide; n-butyllithium; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;