(R)-2-AMino-2-(3-trifluoroMethylphenyl)ethanol

Base Information

• Chemical Name: (R)-2-AMino-2-(3-trifluoroMethylphenyl)ethanol
• CAS No.: 1035490-73-3
• Molecular Formula: C9H11ClF3NO
• Molecular Weight: 241.6379496
• Mol file: 1035490-73-3.mol

Synonyms:(R)-2-AMino-2-(3-trifluoroMethylphenyl)ethanol;(2R)-2-AMINO-2-[3-(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL;(R)-2-aMino-2-(3-(trifluoroMethyl)phenyl)ethanol HCl

Chemical Property of (R)-2-AMino-2-(3-trifluoroMethylphenyl)ethanol

Chemical Property:

• PSA: 46.25000
• LogP: 2.39780
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

(R)-2-Amino-2-(3-(trifluoromethyl)phenyl)ethanol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-AMino-2-(3-trifluoroMethylphenyl)ethanol

There total 7 articles about (R)-2-AMino-2-(3-trifluoroMethylphenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(Rs,1S)-N-(2-(tert-butyldimethylsilyloxy)-1-(3-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide (1312719-15-5) → (S)-2-amino-2-(3-(trifluoromethyl)phenyl)ethanol (325152-99-6,1035490-73-3)

Guidance literature:

(Rs,1S)-N-(2-(tert-butyldimethylsilyloxy)-1-(3-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide; With hydrogenchloride; In methanol; at 20 ℃; for 3h;

With sodium hydrogencarbonate; In water;

DOI:10.1016/j.tetasy.2011.01.011

Reference yield:

C11H7Cl3F3NO → 2-amino-2-(3-trifluoromethylphenyl)ethanol (1094709-76-8,1035490-73-3)

Guidance literature:

With hydrogenchloride; In methanol; water; for 2h;

DOI:10.1002/anie.202008806

Reference yield:

C11H9Cl3F3NO → 2-amino-2-(3-trifluoromethylphenyl)ethanol (1094709-76-8,1035490-73-3)

Guidance literature:

Multi-step reaction with 2 steps

1: cesium iodide; 2,3-dioxaspiro[4.4]nonane-1,4-dione / acetonitrile / 3 h / Irradiation; Inert atmosphere

2: hydrogenchloride / methanol; water / 2 h

With hydrogenchloride; 2,3-dioxaspiro[4.4]nonane-1,4-dione; cesium iodide; In methanol; water; acetonitrile;

DOI:10.1002/anie.202008806

upstream raw materials:

2-(tert-butyldimethylsilyloxy)-1-(3-(trifluoromethyl)phenyl)ethanone

(Rs)-N-(2-(tert-butyldimethylsilyloxy)-1-(3-(trifluoromethyl)phenyl)ethylidene)-2-methylpropane-2-sulfinamide

(Rs,1S)-N-(2-(tert-butyldimethylsilyloxy)-1-(3-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

3-bromo-1-trifluoromethylbenzene

Refernces

• 1、 Pan, Xingang,Jia, Liangbin,Liu, Xuejian,Ma, Haikuo,Yang, Wenqian,Schwarz, Jacob B.. "A general asymmetric synthesis of phenylglycinols". . p. 329 - 337. Retrieved 2011/05/17.