Serotonin β-D-Glucuronide

Base Information

• Chemical Name: Serotonin β-D-Glucuronide
• CAS No.: 18186-43-1
• Molecular Formula: C₁₆H₂₀N₂O₇
• Molecular Weight: 352.344
• Mol file: 18186-43-1.mol

Synonyms:Serotonin β-D-Glucuronide;3-(2-AMinoethyl)-1H-indol-5-yl β-D-Glucopyranosiduronic acid;5-HydroxytryptaMine Glucuronide;5-HydroxytryptaMine O-Glucuronide

Chemical Property of Serotonin β-D-Glucuronide

Chemical Property:

• PSA: 158.26000
• LogP: -0.35960
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Serotonin β-D-Glucuronide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of 5-Hydroxytryptamine, also known as Serotonin (S274990).

Technology Process of Serotonin β-D-Glucuronide

There total 2 articles about Serotonin β-D-Glucuronide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-aminoethyl)-1H-indol-5-ol (50-67-9) + uridine-5'-diphospho-α-D-glucuronic acid trisodium salt (63700-19-6) → serotonin O-glucuronide (18186-43-1)

Guidance literature:

With magnesium chloride; D-Glucaro-1,4-lacton; In phospate buffer; acetonitrile; at 37 ℃; for 7h; pH=7.4; Enzymatic reaction;

DOI:10.1021/ac901320z

Reference yield:

3-(2-aminoethyl)-1H-indol-5-ol (50-67-9) + uridine 5'-diphosphoglucuronic acid trisodium salt → serotonin O-glucuronide (18186-43-1)

Guidance literature:

With human recombinant UDP-glucuronosyltransferase isoform UGT₁A₆; In aq. buffer; at 37 ℃; for 1h; pH=7.4; Reagent/catalyst; Kinetics; Enzymatic reaction;

DOI:10.3109/00498254.2015.1101509

upstream raw materials:

3-(2-aminoethyl)-1H-indol-5-ol

uridine-5'-diphospho-α-D-glucuronic acid trisodium salt

Refernces

• 1、 Uutela, Paeivi,Reinilae, Ruut,Harju, Kirsi,Piepponen, Petteri,Ketola, Raimo A.,Kostiainen, Risto. "Analysis of intact glucuronides and sulfates of serotonin, dopamine, and their phase I metabolites in rat brain microdialysates by liquid chromatography-tandem mass spectrometry". experimental part. p. 8417 - 8425. Retrieved 2010/04/24.