1-(2-O,3-O-Diacetyl-β-D-arabinofuranosyl)uracil

Base Information

• Chemical Name: 1-(2-O,3-O-Diacetyl-β-D-arabinofuranosyl)uracil
• CAS No.: 21016-88-6
• Molecular Formula: C₁₃H₁₆N₂O₈
• Molecular Weight: 328.279
• Mol file: 21016-88-6.mol

Synonyms:1-(2-O,3-O-Diacetyl-β-D-arabinofuranosyl)uracil;2',3'-di-O-acetyl-1-beta-D-arabinofuranosyluracil;2',3'-O-Ac-uridine

Chemical Property of 1-(2-O,3-O-Diacetyl-β-D-arabinofuranosyl)uracil

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

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Technology Process of 1-(2-O,3-O-Diacetyl-β-D-arabinofuranosyl)uracil

There total 5 articles about 1-(2-O,3-O-Diacetyl-β-D-arabinofuranosyl)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-(2,3,5-tri-O-acetyl-β-D-arabinofuranosyl)uracil (14057-18-2) → 2',3'-di-O-acetyl-1-β-D-arabinofuranosyluracil (21016-88-6)

Guidance literature:

With immobilized Candida rugosa lipase; In acetonitrile; at 20 ℃; for 24h; pH=7.0; regioselective reaction; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1002/ejoc.200801096

Reference yield: 34.0%

C15H18N2O9 → 2',3'-Di-O-acetyl-1-β-D-arabinofuranosyl-uracil (21016-88-6)

Guidance literature:

With protease N; In aq. phosphate buffer; acetonitrile; at 20 ℃; for 48h; Reagent/catalyst; Enzymatic reaction;

DOI:10.3390/molecules21121621

Reference yield:

Acetic acid (2R,3R,4S,5R)-4-acetoxy-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester (87875-12-5) → 2',3'-di-O-acetyl-1-β-D-arabinofuranosyluracil (21016-88-6)

Guidance literature:

With acetic acid; at 90 ℃; for 0.25h;

upstream raw materials:

Acetic acid (2R,3R,4S,5R)-4-acetoxy-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester

5'-O-monomethoxytritylarabinouridine

1-(2,3,5-tri-O-acetyl-β-D-arabinofuranosyl)uracil

Downstream raw materials:

C₄₅H₄₆N₅O₁₆P

Sodium; {[(2R,3S,4S,5R)-5-(5-bromo-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]-hydroxy-phosphoryl}-acetate

1-(2,3,5-tri-O-acetyl-β-D-arabinofuranosyl)uracil

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