[4-(4-Methoxyphenyl)pyriMidin-5-yl]Methanol

Base Information

• Chemical Name: [4-(4-Methoxyphenyl)pyriMidin-5-yl]Methanol
• CAS No.: 1263281-18-0
• Molecular Formula: C12H12N2O2
• Molecular Weight: 216.239
• Mol file: 1263281-18-0.mol

Synonyms:[4-(4-Methoxyphenyl)pyriMidin-5-yl]Methanol;4-(4-methoxyphenyl)-5-Pyrimidinemethanol

Chemical Property of [4-(4-Methoxyphenyl)pyriMidin-5-yl]Methanol

Chemical Property:

• PSA: 55.24000
• LogP: 1.64450

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(4-Methoxyphenyl)pyriMidin-5-yl]Methanol

There total 2 articles about [4-(4-Methoxyphenyl)pyriMidin-5-yl]Methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[4-(4-methoxyphenyl)-2-(methylsulfanyl)pyrimidin-5-yl]methanol (1355227-76-7) → [4-(4-methoxyphenyl)pyrimidin-5-yl]methanol (1263281-18-0)

Guidance literature:

With Raney Nickel; In ethanol; for 2h; Reflux;

Reference yield:

ethyl 4-(4-methoxyphenyl)-2-(methylsulfanyl)pyrimidine-5-carboxylate (1355227-74-5) → [4-(4-methoxyphenyl)pyrimidin-5-yl]methanol (1263281-18-0)

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / toluene / 1.5 h / -78 °C

2: Raney Nickel / ethanol / 2 h / Reflux

With diisobutylaluminium hydride; In ethanol; toluene;

Reference yield:

[4-(4-methoxyphenyl)pyrimidin-5-yl]methanol (1263281-18-0) → 4-(4-methoxyphenyl)pyrimidine-5-carbaldehyde (1263286-29-8)

Guidance literature:

With manganese(IV) oxide; In tetrahydrofuran; at 20 ℃;

upstream raw materials:

ethyl 4-(4-methoxyphenyl)-2-(methylsulfanyl)pyrimidine-5-carboxylate

[4-(4-methoxyphenyl)-2-(methylsulfanyl)pyrimidin-5-yl]methanol

Downstream raw materials:

4-(4-methoxyphenyl)pyrimidine-5-carbaldehyde

(2E)-3-[4-(4-methoxyphenyl)pyrimidin-5-yl]prop-2-enoic acid

(2E)-3-[4-(4-methoxyphenyl)pyrimidin-5-yl]-N-{4-[2-(1,3,4-oxadiazol-2-yl)ethyl]phenyl}prop-2-enamide

C₁₆H₁₆N₂O₃

Refernces