1-(Azetidin-3-yl)pyrrolidin-2-one

Base Information

• Chemical Name: 1-(Azetidin-3-yl)pyrrolidin-2-one
• CAS No.: 1257294-05-5
• Molecular Formula: C7H12N2O
• Molecular Weight: 140.185
• Hs Code.: 2933998090
• Mol file: 1257294-05-5.mol

Synonyms:1-(Azetidin-3-yl)pyrrolidin-2-one;1-(Azetidin-3-yl)pyrrolidin-2-one trifluoro acetate;1-(3-Azetidinyl)-2-pyrrolidinone HCl

Chemical Property of 1-(Azetidin-3-yl)pyrrolidin-2-one

Chemical Property:

• PSA: 32.34000
• LogP: -0.15270
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

95+% ^*data from raw suppliers

1-(azetidin-3-yl)pyrrolidin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(Azetidin-3-yl)pyrrolidin-2-one

There total 2 articles about 1-(Azetidin-3-yl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

benzyl 3-(2-oxopyrrolidin-1-yl)azetidine-1-carboxylate → 1-azetidin-3-ylpyrrolidin-2-one (1257294-05-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h; under 775.743 Torr;

Reference yield:

benzyl 3-(4-chlorobutanamido)azetidine-1-carboxylate → 1-azetidin-3-ylpyrrolidin-2-one (1257294-05-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran / 12 h / 25 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C / 775.74 Torr

With palladium 10% on activated carbon; hydrogen; sodium hydroxide; In tetrahydrofuran; methanol;

Reference yield: 31.0%

1-azetidin-3-ylpyrrolidin-2-one (1257294-05-5) + 4,6-dichloro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-d]-pyrimidine → 1-(1-{6-chloro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-d]-pyrimidin-4-yl}azetidin-3-yl)pyrrolidin-2-one

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 2-methyltetrahydrofuran; at 0 - 20 ℃; for 12h;

Refernces