2H-Indazol-3-ol, 4,5,6,7-tetrahydro- (9CI)

Base Information

• Chemical Name: 2H-Indazol-3-ol, 4,5,6,7-tetrahydro- (9CI)
• CAS No.: 402602-24-8
• Molecular Formula: C₇H₁₀N₂O
• Molecular Weight: 138.169
• Hs Code.: 2933998090
• Mol file: 402602-24-8.mol

Synonyms:2H-Indazol-3-ol, 4,5,6,7-tetrahydro- (9CI);4,5,6,7-Tetrahydro-2H-indazol-3-ol

Chemical Property of 2H-Indazol-3-ol, 4,5,6,7-tetrahydro- (9CI)

Chemical Property:

• PSA: 48.91000
• LogP: 0.99410

Purity/Quality:

98%, ^*data from raw suppliers

4,5,6,7-Tetrahydro-2H-indazol-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Indazol-3-ol, 4,5,6,7-tetrahydro- (9CI)

There total 2 articles about 2H-Indazol-3-ol, 4,5,6,7-tetrahydro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1H-indazol-3-ol (7364-25-2,100922-96-1,70010-33-2) → 4,5,6,7-tetrahydro-1H-indazol-3-ol (4344-73-4,402602-24-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; at 50 ℃; for 7h;

DOI:10.1246/bcsj.53.825

Reference yield:

ethyl 2-oxocyclohexane carboxylate (1655-07-8) → 4,5,6,7-tetrahydro-1H-indazol-3-ol (4344-73-4,402602-24-8)

Guidance literature:

With hydrazine hydrate monohydrate; In ethanol; at 20 ℃; for 16h;

Reference yield:

4,5,6,7-tetrahydro-1H-indazol-3-ol (4344-73-4,402602-24-8) → (S)-N-(1-(3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)-6-(3-hydroxy-3-methylbut-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-(3-chloro-4,5,6,7-tetrahydro-2H-indazol-2-yl)acetamide + (S)-N-(1-(3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)-6-(3-hydroxy-3-methylbut-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-(3-chloro-4,5,6,7-tetrahydro-1H-indazol-1-yl)acetamide

Guidance literature:

Multi-step reaction with 2 steps

1.1: trichlorophosphate / 0.25 h / 225 °C / Microwave irradiation; Inert atmosphere

2.1: sodium hydride / N,N-dimethyl acetamide; mineral oil / 0.25 h / 20 °C

2.2: 2 h / 0 - 20 °C

With sodium hydride; trichlorophosphate; In N,N-dimethyl acetamide; mineral oil;

upstream raw materials:

1H-indazol-3-ol

ethyl 2-oxocyclohexane carboxylate

Downstream raw materials:

1-benzyl-3-<3-(dimethylamino)propoxy>-4,5,6,7-tetrahydro-1H-indazole

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