[4-HydroxyMethyl-1-(toluene-4-sulfonyl)-piperidin-4-yl]-Methanol

Base Information

• Chemical Name: [4-HydroxyMethyl-1-(toluene-4-sulfonyl)-piperidin-4-yl]-Methanol
• CAS No.: 1523618-34-9
• Molecular Formula: C14H21NO4S
• Molecular Weight: 299.38584
• Mol file: 1523618-34-9.mol

Synonyms:[4-HydroxyMethyl-1-(toluene-4-sulfonyl)-piperidin-4-yl]-Methanol;[4-(hydroxymethyl)-1-(4-methylbenzenesulfonyl)piperidin-4-yl]methanol;(1-Tosylpiperidine-4,4-diyl)dimethanol

Chemical Property of [4-HydroxyMethyl-1-(toluene-4-sulfonyl)-piperidin-4-yl]-Methanol

Chemical Property:

• Boiling Point: 481.2±51.0 °C(Predicted)
• PKA: 14?+-.0.10(Predicted)
• Density: 1.265±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

[4-Hydroxymethyl-1-(toluene-4-sulfonyl)-piperidin-4-yl]-methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-HydroxyMethyl-1-(toluene-4-sulfonyl)-piperidin-4-yl]-Methanol

There total 2 articles about [4-HydroxyMethyl-1-(toluene-4-sulfonyl)-piperidin-4-yl]-Methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

diethyl 1-(4-methylbenzene-1-sulfonyl)piperidine-4,4-dicarboxylate → [1-(4-methylbenzene-1-sulfonyl)piperidine-4,4-diyl]dimethanol (1523618-34-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.3390/molecules200813864

Reference yield:

N,N-bis(2-bromoethyl)-4-methylbenzenesulfonamide (52601-82-8) → [1-(4-methylbenzene-1-sulfonyl)piperidine-4,4-diyl]dimethanol (1523618-34-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 80 °C

1.2: 12 h / 80 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 20 °C

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.3390/molecules200813864

Reference yield:

[1-(4-methylbenzene-1-sulfonyl)piperidine-4,4-diyl]dimethanol (1523618-34-9) → bis(2-oxa-7-azaspiro[3.5]nonan-7-ium) ethanedioate

Guidance literature:

Multi-step reaction with 3 steps

1: methanesulfonyl chloride; potassium tert-butylate / tetrahydrofuran / 3 h / 20 °C

2: magnesium / methanol / 1 h / Sonication

3: diethyl ether

With potassium tert-butylate; magnesium; methanesulfonyl chloride; In tetrahydrofuran; methanol; diethyl ether;

DOI:10.3390/molecules200813864

upstream raw materials:

N,N-bis(2-bromoethyl)-4-methylbenzenesulfonamide