2-(TETRAHYDRO-FURAN-2-YL)-BENZOOXAZOLE

Base Information

• Chemical Name: 2-(TETRAHYDRO-FURAN-2-YL)-BENZOOXAZOLE
• CAS No.: 327618-31-5
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.214
• Mol file: 327618-31-5.mol

Synonyms:2-(TETRAHYDRO-FURAN-2-YL)-BENZOOXAZOLE;2-(tetrahydro-2-furanyl)Benzoxazole

Chemical Property of 2-(TETRAHYDRO-FURAN-2-YL)-BENZOOXAZOLE

Chemical Property:

• PSA: 35.26000
• LogP: 2.67930

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(TETRAHYDRO-FURAN-2-YL)-BENZOOXAZOLE

There total 7 articles about 2-(TETRAHYDRO-FURAN-2-YL)-BENZOOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-isocyano-1-(2-tetrahydrofuranyloxy)benzene (1355021-17-8) → 2-(tetrahydrofuran-2-yl)benzoxazole (327618-31-5)

Guidance literature:

With 2,4,6-trimethyl-pyridine; boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ol203175a

Reference yield: 80.0%

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + benzoxazole (273-53-0,29791-96-6) → 2-(tetrahydrofuran-2-yl)benzoxazole (327618-31-5)

Guidance literature:

With tert.-butylhydroperoxide; In decane; at 100 ℃; for 24h; Reagent/catalyst; Inert atmosphere;

DOI:10.1039/c8ra01796d

Reference yield: 75.0%

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + 2-chloro-1,3-benzoxazole (615-18-9) → 2-(tetrahydrofuran-2-yl)benzoxazole (327618-31-5)

Guidance literature:

With trifluorormethanesulfonic acid; Selectfluor; copper(I) bromide; In acetonitrile; at 50 ℃; for 5h;

upstream raw materials:

tetrahydrofuran

benzoxazole

N-(2-(2-tetrahydrofuranyloxy)phenyl)formamide

2-isocyano-1-(2-tetrahydrofuranyloxy)benzene

Refernces

• 1、 -. "Method for preparing N-heterocyclic aromatic hydrocarbon derivatives by dehalogenation and alkylation". Paragraph 0068-0070. . Retrieved 2019/05/22.
• 2、 Nauth, Alexander M.,Lipp, Alexander,Lipp, Benjamin,Opatz, Till. "Sunflow: Sunlight Drives Fast and Green Photochemical Flow Reactions in Simple Microcapillary Reactors – Application to Photoredox and H-Atom-Transfer Chemistry". supporting information. p. 2099 - 2103. Retrieved 2017/04/24.