Technology Process of D-Nor-5α-androstan-16β-ol
There total 11 articles about D-Nor-5α-androstan-16β-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: NaOH, aq. NH3, KOCl
2: NaHCO3 / tetrahydrofuran; H2O / Irradiation
4: MCPBA, TsOH / 120 h
With
ammonium hydroxide; sodium hydroxide; potassium hypochlorite; sodium hydrogencarbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; water;
DOI:10.1021/ja00759a040
- Guidance literature:
-
Multi-step reaction with 3 steps
1: NaHCO3 / tetrahydrofuran; H2O / Irradiation
3: MCPBA, TsOH / 120 h
With
sodium hydrogencarbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; water;
DOI:10.1021/ja00759a040
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 8.345 g / hydrogen / Adams' platinum / acetic acid / 24 h
2: 81 percent / Jones reagent / acetone / 1.5 h / 0 °C
3: 90 percent / KOH, hydrazine / various solvent(s) / 2.5 h / Heating
4: 90 percent / diethyl ether; benzene / 1 h / Ambient temperature
5: m-chloroperbenzoic acid, p-toluenesulfonic acid / CH2Cl2 / 139 h / Ambient temperature
6: KOH / methanol / 2 h / Ambient temperature
With
potassium hydroxide; jones reagent; hydrogen; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; hydrazine;
platinum(IV) oxide;
In
methanol; diethyl ether; dichloromethane; acetic acid; acetone; benzene;
DOI:10.1246/bcsj.53.2285
