3-(S)-N-BOC-1-PYRROLIDINEACETIC ACID

Base Information

• Chemical Name: 3-(S)-N-BOC-1-PYRROLIDINEACETIC ACID
• CAS No.: 299203-95-5
• Molecular Formula: C₁₁H₂₀N₂O₄
• Molecular Weight: 244.291
• Hs Code.: 2933990090
• Mol file: 299203-95-5.mol

Synonyms:3-(S)-N-BOC-1-PYRROLIDINEACETIC ACID

Chemical Property of 3-(S)-N-BOC-1-PYRROLIDINEACETIC ACID

Chemical Property:

• PSA: 82.36000
• LogP: 0.81230

Purity/Quality:

≥95% ^*data from raw suppliers

((S)-3-tert-Butoxycarbonylamino-pyrrolidin-1-yl)-aceticacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(S)-N-BOC-1-PYRROLIDINEACETIC ACID

There total 2 articles about 3-(S)-N-BOC-1-PYRROLIDINEACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-acetic acid ethyl ester → (3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-acetic acid (299203-95-5)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1021/jm990468g

Reference yield:

3(S)-(tert-butoxycarbonylamino)pyrrolidine (122536-76-9,140629-77-2) → (3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-acetic acid (299203-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: diisopropylethylamine / acetonitrile / Heating

2: aq. sodium hydroxide / methanol

With sodium hydroxide; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile; 1: Acylation / 2: Hydrolysis;

DOI:10.1021/jm990468g

Reference yield:

(3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-acetic acid (299203-95-5) → 3-[(phenylsulfonyl)amino]-N-[cis-1,2,3,4-tetrahydro-6-fluoro-1-(3-pyridinylmethyl)-2-naphthalenyl]-1(S)-pyrrolidineacetamide bis-trifluoroacetate

Guidance literature:

Multi-step reaction with 3 steps

1: HBTU; DIEA / dimethylformamide / 20 °C

2: CH₂Cl₂; H₂O / 20 °C

3: DIEA / acetonitrile / 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 1: Acylation / 2: Hydrolysis / 3: Sulfonylation;

DOI:10.1021/jm990468g

upstream raw materials:

3(S)-(tert-butoxycarbonylamino)pyrrolidine