N-Hydroxy-4-(2H-indazol-2-yl)-alpha-methylbenzeneacetamide

Base Information

• Chemical Name: N-Hydroxy-4-(2H-indazol-2-yl)-alpha-methylbenzeneacetamide
• CAS No.: 81265-80-7
• Molecular Formula: C₁₆H₁₅N₃O₂
• Molecular Weight: 281.314
• DSSTox Substance ID: DTXSID001001900
• Mol file: 81265-80-7.mol

Synonyms:81265-80-7;M.G. 18803;N-Hydroxy-4-(2H-indazol-2-yl)-alpha-methylbenzeneacetamide;Benzeneacetamide, N-hydroxy-4-(2H-indazol-2-yl)-alpha-methyl-;Acido 2-(4-(2H-indazol-2-il)fenil)propionidrossammico [Italian];2-(4-(2H-Indazol-2-yl)phenyl)-N-hydroxypropanamide;Acido 2-(4-(2H-indazol-2-il)fenil)propionidrossammico;DTXSID001001900;LS-28553;N-Hydroxy-2-[4-(2H-indazol-2-yl)phenyl]propanimidic acid

Chemical Property of N-Hydroxy-4-(2H-indazol-2-yl)-alpha-methylbenzeneacetamide

Chemical Property:

• PSA: 70.64000
• Density: 1.28g/cm³
• LogP: 3.47470
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 281.116426730
• Heavy Atom Count: 21
• Complexity: 369

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=C(C=C1)N2C=C3C=CC=CC3=N2)C(=O)NO

Technology Process of N-Hydroxy-4-(2H-indazol-2-yl)-alpha-methylbenzeneacetamide

There total 3 articles about N-Hydroxy-4-(2H-indazol-2-yl)-alpha-methylbenzeneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

estere etilico dell'acido 2-<4-(2H-indazol-2-il)fenil>propionico (81265-53-4) → acido 2-<4-(2H-indazol-2-il)fenil>propionidrossammico (81265-80-7)

Guidance literature:

With potassium hydroxide; hydroxylamine hydrochloride; In methanol; for 4h; Ambient temperature;

Reference yield:

2-(4-amminofenil)propionico d'etile (32868-25-0) → acido 2-<4-(2H-indazol-2-il)fenil>propionidrossammico (81265-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) triethyl phosphite / 1.) methanol, 4 h, reflux; 2.) 8 h, 150 deg C

2: 63 percent / hydroxylamine hydrochloride, potassium hydroxide / methanol / 4 h / Ambient temperature

With potassium hydroxide; hydroxylamine hydrochloride; triethyl phosphite; In methanol;

Reference yield:

2-nitro-benzaldehyde (552-89-6) → acido 2-<4-(2H-indazol-2-il)fenil>propionidrossammico (81265-80-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) triethyl phosphite / 1.) methanol, 4 h, reflux; 2.) 8 h, 150 deg C

2: 63 percent / hydroxylamine hydrochloride, potassium hydroxide / methanol / 4 h / Ambient temperature

With potassium hydroxide; hydroxylamine hydrochloride; triethyl phosphite; In methanol;

upstream raw materials:

estere etilico dell'acido 2-<4-(2H-indazol-2-il)fenil>propionico

2-(4-amminofenil)propionico d'etile

2-nitro-benzaldehyde