4-Chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Base Information

Chemical Name:4-Chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine
CAS No.:208459-81-8
Molecular Formula:C12H8ClN3
Molecular Weight:229.669
Hs Code.:
DSSTox Substance ID:DTXSID10467625
Wikidata:Q82294663
Mol file:208459-81-8.mol

Synonyms:4-Chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine;208459-81-8;SCHEMBL3226104;DTXSID10467625;YDDOENFAKYOBJS-UHFFFAOYSA-N;MFCD12964287;AKOS015851121;AKOS037646117;AS-66677;CS-0036309;FT-0762614;W10448;4-chloro-5-phenyl-1H-pyrrolo[2,3-d]pyrimidine;4-chloro-(5-phenyl)-7H-pyrrolo[2,3-d] pyrimidine;4-chloro-(5-phenyl)-7H-pyrrolo[2,3-d]pyrimidine

Suppliers and Price of 4-Chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
4-Chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine 95+%
1g
$ 403.00

Chemenu
4-Chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine 95%
10g
$ 1714.00

Chemenu
4-Chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine 95%
5g
$ 1143.00

Chemenu
4-Chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine 95%
1g
$ 381.00

Total 8 raw suppliers

Chemical Property of 4-Chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Chemical Property:

Boiling Point:369.7±52.0 °C(Predicted)
PKA:11.15±0.20(Predicted)
PSA：41.57000
Density:1.40±0.1 g/cm3(Predicted)
LogP:3.27830
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:229.0406750
Heavy Atom Count:16
Complexity:242

Purity/Quality:

98%Min ^*data from raw suppliers

4-Chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CNC3=C2C(=NC=N3)Cl
Description 4-Chloro-5-phenyl-7H-pyrrolo [2, 3-d] pyrimidine is a kind of pyrrolopyrimidine deriviative. Pyrrolopyrinmidine derivatives have been shown to exhibit promoting antihyperglycemic activity, being comparable to a well-known standard antihyperglycemic drug, Glimepiride. Pyrrolo [2, 3-d] pyrimidine derivatives have an important role in modern medicine and have shown marked antitumor and antiviral activity.

Technology Process of 4-Chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

There total 10 articles about 4-Chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 871671-45-3
5-phenylpyrrolo-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one

: 208459-81-8
4-chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: With trichlorophosphate; at 120 ℃; for 2.5h;
DOI:10.1021/jm050394a

Reference yield:

: 2-[(4-chloro-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyltrimethyl-silane

: 208459-81-8
4-chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 16h; Inert atmosphere;

Reference yield:

: 54760-24-6
2-amino-4-phenyl-1H-pyrrole-3-carboxylic acid amide

: 208459-81-8
4-chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / p-toluenesulfonic acid monohydrate / dimethylformamide / 16 h / 20 °C

2: 84 percent / POCl₃ / 2.5 h / 120 °C

With toluene-4-sulfonic acid; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1021/jm050394a