2-Chloro-3'-fluoro-3,4'-dihydroxy-[1,1-biphenyl]-4-carboxaldehydeoxime

Base Information

• Chemical Name: 2-Chloro-3'-fluoro-3,4'-dihydroxy-[1,1-biphenyl]-4-carboxaldehydeoxime
• CAS No.: 1111084-78-6
• Molecular Formula: C13H9CIFNO3
• Molecular Weight: 281.67
• Mol file: 1111084-78-6.mol

Synonyms:2-Chloro-3'-fluoro-3,4'-dihydroxy-[1,1-biphenyl]-4-carboxaldehydeoxime;FERb 033

Chemical Property of 2-Chloro-3'-fluoro-3,4'-dihydroxy-[1,1-biphenyl]-4-carboxaldehydeoxime

Chemical Property:

• Boiling Point: 410.8±45.0 °C(Predicted)
• PKA: 7.17±0.45(Predicted)
• PSA: 73.05000
• Density: 1.45±0.1 g/cm3(Predicted)
• LogP: 3.36540
• Storage Temp.: Store at +4°C

Purity/Quality:

≥98% by HPLC ^*data from raw suppliers

FERb 033 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: FERb 033 is a synthetic, non-steroidal estrogen and a selective ERβ agonist.

Technology Process of 2-Chloro-3'-fluoro-3,4'-dihydroxy-[1,1-biphenyl]-4-carboxaldehydeoxime

There total 1 articles about 2-Chloro-3'-fluoro-3,4'-dihydroxy-[1,1-biphenyl]-4-carboxaldehydeoxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-chloro-4-(3-fluoro-4-hydroxyphenyl)salicylaldehyde (1111084-91-3) → (E)-3-chloro-4-(3-fluoro-4-hydroxyphenyl)salicylaldoxime (1111084-78-6)

Guidance literature:

With hydroxylamine hydrochloride; In ethanol; water; at 50 ℃; for 5h;

DOI:10.1021/jm801458t

upstream raw materials:

3-chloro-4-(3-fluoro-4-hydroxyphenyl)salicylaldehyde