(3-Bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)(2-chloro-6-(trifluoromethyl)phenyl)methanone

Base Information

• Chemical Name: (3-Bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)(2-chloro-6-(trifluoromethyl)phenyl)methanone
• CAS No.: 1414958-43-2
• Molecular Formula: C14H6BrClF3N3O
• Molecular Weight: 404.573
• Mol file: 1414958-43-2.mol

Synonyms:(3-Bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)(2-chloro-6-(trifluoromethyl)phenyl)methanone;(3-Bromo-pyrazolo[4,3-b]pyridin-1-yl)-(2-chloro-6-trifluoromethyl-phenyl)-methanone

Chemical Property of (3-Bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)(2-chloro-6-(trifluoromethyl)phenyl)methanone

Chemical Property:

• PSA: 47.78000
• LogP: 4.55450

Purity/Quality:

97% ^*data from raw suppliers

(3-Bromopyrazolo[4,3-B]Pyridin-1-Yl)-[2-Chloro-6-(Trifluoromethyl)Phenyl]Methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-Bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)(2-chloro-6-(trifluoromethyl)phenyl)methanone

There total 2 articles about (3-Bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)(2-chloro-6-(trifluoromethyl)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

2-chloro-6-(trifluoromethyl)benzoyl chloride (916420-44-5) + 3-bromo-1H-pyrazolo[4,3-b]pyridine (633328-33-3) → (3-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)(2-chloro-6-(trifluoro methyl)phenyl)methanone (1414958-43-2)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 40 ℃; for 3h;

Reference yield: 46.0%

2-chloro-6-(trifluoromethyl)benzoyl chloride (916420-44-5) + 3-bromo-1H-pyrazolo[4,3-b]pyridine (633328-88-8) → (3-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)(2-chloro-6-(trifluoro methyl)phenyl)methanone (1414958-43-2)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 40 ℃; for 3h;

Reference yield: 40.0%

pyrrolidine-3-carboxylic acid (59378-87-9,68464-02-8,72580-53-1,72580-54-2) + (3-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)(2-chloro-6-(trifluoro methyl)phenyl)methanone (1414958-43-2) → 1-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)pyrrolidine-3-carboxylic acid (1561769-37-6)

Guidance literature:

With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; In water; at 100 ℃; for 12h; Inert atmosphere;

upstream raw materials:

2-chloro-6-(trifluoromethyl)benzoyl chloride

3-bromo-1H-pyrazolo[4,3-b]pyridine

3-bromo-1H-pyrazolo[4,3-b]pyridine

Downstream raw materials:

1-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)pyrrolidine-3-carboxylic acid

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)cyclohex-3-enecarboxylic acid

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