4-Thia-1-azabicyclo 3.2.0 heptane-2-carboxylic acid, 3,3-diMethyl-6- (4-Methylbe

Base Information

• Chemical Name: 4-Thia-1-azabicyclo 3.2.0 heptane-2-carboxylic acid, 3,3-diMethyl-6- (4-Methylbe
• CAS No.: 81075-79-8
• Molecular Formula: C₂₉H₂₈N₂O₅S
• Molecular Weight: 516.618

Synonyms:4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-6-[(4-methylbenzoyl)amino]-7-oxo-, diphenylmethyl ester, 4-oxide, [2S-(2α,5α,6β)]- (9CI)

Chemical Property of 4-Thia-1-azabicyclo 3.2.0 heptane-2-carboxylic acid, 3,3-diMethyl-6- (4-Methylbe

Chemical Property:

• PSA: 111.99000
• LogP: 4.69850

Purity/Quality:

99.0% Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Thia-1-azabicyclo 3.2.0 heptane-2-carboxylic acid, 3,3-diMethyl-6- (4-Methylbe

There total 8 articles about 4-Thia-1-azabicyclo 3.2.0 heptane-2-carboxylic acid, 3,3-diMethyl-6- (4-Methylbe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.8%

1,1-Diphenylmethanol (91-01-0) + 6β-(4-toluamido)penicillanic acid 1-oxide (81016-97-9) → diphenylmethyl 6β-(4-toluamido)penicillate 1-oxide (67977-95-1,77887-68-4,80756-34-9,82468-41-5,81075-79-8)

Guidance literature:

With pyridine; 1,3,5-trichloro-2,4,6-triazine; In dichloromethane; at -20 - -15 ℃; for 1.33333h;

DOI:10.3987/COM-90-5565

Reference yield: 93.0%

(S)-3,3-Dimethyl-6-(4-methyl-benzoylamino)-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester (104101-66-8) → (S)-3,3-Dimethyl-6-(4-methyl-benzoylamino)-4,7-dioxo-4λ4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester (67977-95-1,77887-68-4,80756-34-9,81075-79-8,82468-41-5)

Guidance literature:

With formic acid; dihydrogen peroxide; In dichloromethane; at 0 - 25 ℃; for 4h;

DOI:10.1055/s-1989-27194

Reference yield:

6β-(4-toluamido)penicillanic acid (17028-66-9) + benzophenone hydrazone (5350-57-2) → diphenylmethyl 6β-(4-toluamido)penicillate 1-oxide (67977-95-1,77887-68-4,80756-34-9,82468-41-5,81075-79-8)

Guidance literature:

With sulfuric acid; dihydrogen peroxide; acetic acid; In dichloromethane; water; at 3 - 11 ℃; for 9h; Large scale;

upstream raw materials:

1,1-Diphenylmethanol

6β-(4-toluamido)penicillanic acid 1-oxide

6β-(4-toluamido)penicillanic acid

diphenylmethyl 6β-(4-toluamido)penicillanate

Downstream raw materials:

C₂₉H₂₈N₂O₅S

C₂₉H₂₆N₂O₄

diphenylmethyl (2R,6R,7R)-3-methylene-7-[(4-methylbenzoyl)amino]-8-oxo-5-oxa-1-azabicyclo[4.2.0]octane-2-carboxylate

(6R,7R)-benzhydryl (7-(2-difluoromethylthio)acetamido)-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4,2,0]oct-2-ene-2-carboxylate

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