3-O-(TERT-BUTYLDIMETHYLSILYLOXY)-ERYTHRO-SPHINGOSINE

Base Information

Chemical Name:3-O-(TERT-BUTYLDIMETHYLSILYLOXY)-ERYTHRO-SPHINGOSINE
CAS No.:137905-29-4
Molecular Formula:C24H51NO2Si
Molecular Weight:413.76
Hs Code.:
Mol file:137905-29-4.mol

Synonyms:3-O-(TERT-BUTYLDIMETHYLSILYLOXY)-ERYTHRO-SPHINGOSINE;(2S,3R,4E)-2-AMINO-3-(TERTBUTYLDIMETHYLSILYLOXY)-4-OCTADECENE-1-OL

Suppliers and Price of 3-O-(TERT-BUTYLDIMETHYLSILYLOXY)-ERYTHRO-SPHINGOSINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
3-O-(tert-Butyldimethylsilyloxy)-erythro-sphingosine
50 mg
$ 2000.00

American Custom Chemicals Corporation
3-O-(TERT-BUTYLDIMETHYLSILYLOXY)-ERYTHRO-SPHINGOSINE 95.00%
100MG
$ 1732.50

American Custom Chemicals Corporation
3-O-(TERT-BUTYLDIMETHYLSILYLOXY)-ERYTHRO-SPHINGOSINE 95.00%
10MG
$ 292.95

Total 3 raw suppliers

Chemical Property of 3-O-(TERT-BUTYLDIMETHYLSILYLOXY)-ERYTHRO-SPHINGOSINE

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:482.728°C at 760 mmHg
Flash Point:245.745°C
PSA：55.48000
Density:0.895g/cm³
LogP:7.65400
Solubility.:Acetone, Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

98%Min ^*data from raw suppliers

3-O-(tert-Butyldimethylsilyloxy)-erythro-sphingosine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A derivative of Sphingosine, a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes; natural isomer of sphingosine.

Technology Process of 3-O-(TERT-BUTYLDIMETHYLSILYLOXY)-ERYTHRO-SPHINGOSINE

There total 1 articles about 3-O-(TERT-BUTYLDIMETHYLSILYLOXY)-ERYTHRO-SPHINGOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 114299-64-8
(2S,3S,4E)-2-azido-3-O-(tert-butyldimethylsilyl)-4-octadecen-1,3-diol

: 137905-29-4
(2S,3R,4E)-2-amino-3-(tert-butyldimethylsilyloxy)-4-octadecene-1-ol

Guidance literature:: With pyridine; water; triphenylphosphine; at 55 - 60 ℃; for 11h;
DOI:10.1016/S0040-4039(00)92367-0

Reference yield: 92.0%

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 137905-29-4
(2S,3R,4E)-2-amino-3-(tert-butyldimethylsilyloxy)-4-octadecene-1-ol

: 149035-77-8
(2S,3R,4E)-3-(tert-butyldimethylsilyloxy)-2-(9-fluorenylmethyloxycarbonylamino)-4-octadecene-1-ol

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; water;
DOI:10.1016/S0040-4039(00)60772-4

Reference yield:

: 137905-29-4
(2S,3R,4E)-2-amino-3-(tert-butyldimethylsilyloxy)-4-octadecene-1-ol

: 26993-30-6,26993-39-5
Sphingosine-1-phosphate

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / NaHCO₃ / dioxane; H₂O

2: tetrazole / CH₂Cl₂; acetonitrile / 0.5 h

3: iodine, pyridine, water / CH₂Cl₂

4: 95 percent / 33percent HNMe₂ / ethanol / 72 h / 45 °C

5: 75 percent / tetrabutylammonium fluoride / tetrahydrofuran / 72 h / 45 °C

With pyridine; 1H-tetrazole; tetrabutyl ammonium fluoride; water; iodine; sodium hydrogencarbonate; dimethyl amine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4039(00)60772-4