6,7-dichlorobenzo[b]thiophene

Base Information

• Chemical Name: 6,7-dichlorobenzo[b]thiophene
• CAS No.: 439083-10-0
• Molecular Formula: C₈H₄Cl₂S
• Molecular Weight: 203.092
• Mol file: 439083-10-0.mol

Synonyms:6,7-dichlorobenzo[b]thiophene

Chemical Property of 6,7-dichlorobenzo[b]thiophene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

6,7-Dichlorobenzo[b]thiophene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 6,7-dichlorobenzo[b]thiophene

There total 1 articles about 6,7-dichlorobenzo[b]thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

6,7-dichloro-2,3-dihydro-1-benzothiophene-3-ol → 6,7-dichloro-1-benzothiophene (439083-10-0)

Guidance literature:

With boron trifluoride diethyl etherate; acetic acid; In diethyl ether; for 0.5h; Inert atmosphere;

DOI:10.1016/j.bmcl.2016.07.038

Reference yield:

6,7-dichloro-1-benzothiophene (439083-10-0) → (±)-N-(6,7-dichloro-1,1-dioxido-2,3-dihydro-1-benzothiophen-3-yl)-N-[2-(dimethylamino)ethyl]-3-(4-fluoro-3-methylphenyl)-5-methoxyimidazo[1,2-a]pyridine-2-carboxamide

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tungstate (VI) dihydrate; dihydrogen peroxide / methanol; acetic acid

2: ethanol / 72 h / 20 - 40 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; pyridine / tetrahydrofuran / 6 h

With pyridine; sodium tungstate (VI) dihydrate; dihydrogen peroxide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; ethanol; acetic acid;

DOI:10.1016/j.bmcl.2016.07.038

Reference yield:

6,7-dichloro-1-benzothiophene (439083-10-0) → (+)-N-(6,7-dichloro-1,1-dioxido-2,3-dihydro-1-benzothiophen-3-yl)-N-[2-(dimethylamino)ethyl]-3-(4-fluoro-3-methylphenyl)-5-methoxyimidazo[1,2-a]pyridine-2-carboxamide + C28H27Cl2FN4O4S

Guidance literature:

Multi-step reaction with 4 steps

1: sodium tungstate (VI) dihydrate; dihydrogen peroxide / methanol; acetic acid

2: ethanol / 72 h / 20 - 40 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; pyridine / tetrahydrofuran / 6 h

4: CHIRALCEL OD (CA₀₀₂) / hexane; ethanol / Resolution of racemate

With pyridine; sodium tungstate (VI) dihydrate; dihydrogen peroxide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; ethanol; hexane; acetic acid;

DOI:10.1016/j.bmcl.2016.07.038

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