Hexahydro-1H-furo[3,4-c]pyrrole hydrochloride

Base Information

• Chemical Name: Hexahydro-1H-furo[3,4-c]pyrrole hydrochloride
• CAS No.: 60889-33-0
• Molecular Formula: C6H12ClNO
• Molecular Weight: 149.61858
• Mol file: 60889-33-0.mol

Synonyms:Hexahydro-1H-furo[3,4-c]pyrrole hydrochloride

Chemical Property of Hexahydro-1H-furo[3,4-c]pyrrole hydrochloride

Chemical Property:

• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Hexahydro-1H-furo[3,4-c]pyrrole hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Hexahydro-?1H-?furo[3,?4-?c]?pyrrole hydrochloride is used as a reactant in the preparation of hexahydro-?1H-?furo(3,?4-?c) pyrrole compounds for the treatment of pain.

Technology Process of Hexahydro-1H-furo[3,4-c]pyrrole hydrochloride

There total 5 articles about Hexahydro-1H-furo[3,4-c]pyrrole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cis-5-benzylhexahydro-1H-furo[3,4-c]pyrrole hydrochloride → cis‐hexahydro‐1H‐furo[3,4‐c]pyrrol‐5‐ium chloride (60889-33-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h;

DOI:10.1055/s-0036-1588785

Reference yield:

cis-(1-benzylpyrrolidine-3,4-diyl)dimethanol (179601-65-1,1345831-65-3) → cis‐hexahydro‐1H‐furo[3,4‐c]pyrrol‐5‐ium chloride (60889-33-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h

1.2: 3 h / 20 °C / Reflux

2.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane

3.1: hydrogen; palladium 10% on activated carbon / methanol / 12 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; In tetrahydrofuran; 1,4-dioxane; methanol;

DOI:10.1055/s-0036-1588785

Reference yield:

cis-5-benzyltetrahydro-1H-furo[3,4-c]pyrrole-1,3(3aH)-dione (1221289-17-3,885956-73-0) → cis‐hexahydro‐1H‐furo[3,4‐c]pyrrol‐5‐ium chloride (60889-33-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 25 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.25 h

2.2: 3 h / 20 °C / Reflux

3.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane

4.1: hydrogen; palladium 10% on activated carbon / methanol / 12 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; In tetrahydrofuran; 1,4-dioxane; methanol;

DOI:10.1055/s-0036-1588785

upstream raw materials:

cis-(1-benzylpyrrolidine-3,4-diyl)dimethanol

cis-5-benzyltetrahydro-1H-furo[3,4-c]pyrrole-1,3(3aH)-dione

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