SKLB 610

Base Information

• Chemical Name: SKLB 610
• CAS No.: 1125780-41-7
• Molecular Formula: C21H16F3N3O3
• Molecular Weight: 415.3652496
• Mol file: 1125780-41-7.mol

Synonyms:SKLB 610;N-Methyl-4-[4-[3-(trifluoromethyl)benzamido]phenoxy]-2-picolinamide;N-Methyl-4-[4-[3-(trifluoromethyl)benzamido]phenoxy]-2-picolinamide SKLB 610;SKLB 610 N-Methyl-4-[4-[3-(trifluoromethyl)benzamido]phenoxy]-2-picolinamide;SKLB 610, >=98%

Chemical Property of SKLB 610

Chemical Property:

• Boiling Point: 500.9±50.0 °C(Predicted)
• PKA: 12.23±0.70(Predicted)
• PSA: 80.32000
• Density: 1.357±0.06 g/cm3(Predicted)
• LogP: 4.96850
• Solubility.: insoluble in H2O; ≥20.75 mg/mL in DMSO; ≥23 mg/mL in EtOH with ultrasonic

Purity/Quality:

98%,99%, ^*data from raw suppliers

SKLB610 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of SKLB 610

There total 5 articles about SKLB 610 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide (284462-37-9) + 3-(Trifluoromethyl)benzoyl chloride (2251-65-2) → N-methyl-4-(4-(3-(trifluoromethyl)benzamido)phenoxy)picolinamide (1125780-41-7)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.3390/molecules26041150

Reference yield:

4-chloro-2-pyridine carboxylic acid chloride hydrochloride (51727-15-2) → N-methyl-4-(4-(3-(trifluoromethyl)benzamido)phenoxy)picolinamide (1125780-41-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 16.42 h / 0 - 20 °C / Inert atmosphere

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2.02 h / Inert atmosphere

2.2: 4 h / 80 °C / Inert atmosphere

3.1: pyridine / dichloromethane / 14 h / Inert atmosphere

With pyridine; potassium tert-butylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

4-chloro-N-methylpicolinamide (220000-87-3) → N-methyl-4-(4-(3-(trifluoromethyl)benzamido)phenoxy)picolinamide (1125780-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 2.02 h / Inert atmosphere

1.2: 4 h / 80 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 14 h / Inert atmosphere

With pyridine; potassium tert-butylate; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

3-(Trifluoromethyl)benzoyl chloride

4-chloropicolinic acid

4-chloro-2-pyridine carboxylic acid chloride hydrochloride

Downstream raw materials:

N-methyl-4-(4-(3-(trifluoromethyl)benzamido)phenoxy)picolinamide 4-methylbenzenesulfonate

Refernces

• 1、 -. "KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER". Paragraph 00188. . Retrieved 2018/03/09.