4-Bromo-2,6-dichlorobenzyl alcohol

Base Information

• Chemical Name: 4-Bromo-2,6-dichlorobenzyl alcohol
• CAS No.: 274671-77-1
• Molecular Formula: C7H5BrCl2O
• Molecular Weight: 255.926
• Mol file: 274671-77-1.mol

Synonyms:4-Bromo-2,6-dichlorobenzyl alcohol;4-bromo-2,6-dichlorobenzenemethanol

Chemical Property of 4-Bromo-2,6-dichlorobenzyl alcohol

Chemical Property:

• Boiling Point: 325.2±37.0 °C(Predicted)
• PKA: 13.18±0.10(Predicted)
• PSA: 20.23000
• Density: 1.785±0.06 g/cm3(Predicted)
• LogP: 3.24820

Purity/Quality:

99% ^*data from raw suppliers

(4-Bromo-2,6-dichlorophenyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-2,6-dichlorobenzyl alcohol

There total 4 articles about 4-Bromo-2,6-dichlorobenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-(bromomethyl)-1,3-dichlorobenzene (274671-76-0) → 4-bromo-2,6-dichlorobenzyl alcohol (274671-77-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 12 h / 20 °C

2: 2.35 g / NaOH / ethanol; H₂O / 1 h

With sodium hydroxide; In ethanol; water; acetonitrile; 1: Substitution / 2: Hydrolysis;

Reference yield:

4-bromo-2,6-dichlorobenzyl acetate → 4-bromo-2,6-dichlorobenzyl alcohol (274671-77-1)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 1h;

Reference yield:

3,5-dichloro-4-methylaniline (54730-35-7) → 4-bromo-2,6-dichlorobenzyl alcohol (274671-77-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 48percent HBr; NaNO₂ / H₂O / 0.17 h / 5 °C

1.2: 52 percent / 48percent HBr; CuBr / 0.5 h / 50 °C

2.1: 96 percent / N-bromosuccinimide / CCl₄ / 2 h / Irradiation

3.1: acetonitrile / 12 h / 20 °C

4.1: 2.35 g / NaOH / ethanol; H₂O / 1 h

With sodium hydroxide; N-Bromosuccinimide; sodium nitrite; In tetrachloromethane; ethanol; water; acetonitrile; 1.1: Diazotization / 1.2: Substitution / 2.1: Bromination / 3.1: Substitution / 4.1: Hydrolysis;

upstream raw materials:

3,5-dichloro-4-methylaniline

4-bromo-2,6-dichlorotoluene

5-bromo-2-(bromomethyl)-1,3-dichlorobenzene

Downstream raw materials:

4-bromo-2,6-dichlorobenzaldehyde