2-{[tert-Butyl(dimethyl)silyl]oxy}-1-(4-fluorophenyl)ethan-1-one

Base Information

Chemical Name:2-{[tert-Butyl(dimethyl)silyl]oxy}-1-(4-fluorophenyl)ethan-1-one
CAS No.:935534-38-6
Molecular Formula:C14H21FO2Si
Molecular Weight:268.403
Hs Code.:2931900090
DSSTox Substance ID:DTXSID90702889
Nikkaji Number:J2.953.391A
Wikidata:Q82634911
Mol file:935534-38-6.mol

Synonyms:935534-38-6;SCHEMBL3100978;DTXSID90702889;alpha-(tert-Butyldimethylsilyloxy)-4'-fluoroacetophenone;2-(tert-Butyl-dimethylsilanyloxy)-1-(4-fluorophenyl)-ethanone;2-{[tert-Butyl(dimethyl)silyl]oxy}-1-(4-fluorophenyl)ethan-1-one

Suppliers and Price of 2-{[tert-Butyl(dimethyl)silyl]oxy}-1-(4-fluorophenyl)ethan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-(TERT-BUTYL-DIMETHYL-SILANYLOXY)-1-(4-FLUORO-PHENYL)-ETHANONE 95.00%
5MG
$ 495.62

Total 0 raw suppliers

Chemical Property of 2-{[tert-Butyl(dimethyl)silyl]oxy}-1-(4-fluorophenyl)ethan-1-one

Chemical Property:

PSA：26.30000
LogP:4.03020
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:268.12948460
Heavy Atom Count:18
Complexity:289

Purity/Quality:: 2-(TERT-BUTYL-DIMETHYL-SILANYLOXY)-1-(4-FLUORO-PHENYL)-ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OCC(=O)C1=CC=C(C=C1)F

Technology Process of 2-{[tert-Butyl(dimethyl)silyl]oxy}-1-(4-fluorophenyl)ethan-1-one

There total 6 articles about 2-{[tert-Butyl(dimethyl)silyl]oxy}-1-(4-fluorophenyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 163089-34-7
N-methoxy-N-methyl-2-(1,1,2,2-tetramethyl-1-silapropoxy)acetamide

: 460-00-4
1-Bromo-4-fluorobenzene

: 935534-38-6
2-((tert-butyldimethylsilyl)oxy)-1-(4-fluorophenyl)ethanone

Guidance literature:: 1-Bromo-4-fluorobenzene; With magnesium; ethylene dibromide; In tetrahydrofuran; at 20 ℃; for 0.666667h; Inert atmosphere;

N-methoxy-N-methyl-2-(1,1,2,2-tetramethyl-1-silapropoxy)acetamide; In tetrahydrofuran; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.tetasy.2011.01.011

Reference yield:

: 231301-08-9
tert-butyl((1-(4-fluorophenyl)vinyl)oxy)dimethylsilane

: 935534-38-6
2-((tert-butyldimethylsilyl)oxy)-1-(4-fluorophenyl)ethanone

Guidance literature:: With 2,2,2-Trifluoroacetophenone; dihydrogen peroxide; In acetonitrile; tert-butyl alcohol; at 20 ℃; for 1h; Green chemistry;
DOI:10.1039/c6ob00036c

Reference yield:

: 456-04-2
2-Chloro-4'-fluoroacetophenone

: 935534-38-6
2-((tert-butyldimethylsilyl)oxy)-1-(4-fluorophenyl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 10 h / 90 °C

2: potassium carbonate; methanol / 2 h / 20 °C

3: triethylamine / dmap / dichloromethane; acetonitrile / 10 h / 20 °C

With methanol; potassium carbonate; triethylamine; dmap; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;