1-benzofuran-3-ylMethanaMine

Base Information

• Chemical Name: 1-benzofuran-3-ylMethanaMine
• CAS No.: 165735-63-7
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.177
• Mol file: 165735-63-7.mol

Synonyms:1-benzofuran-3-ylMethanaMine;3-(Aminomethyl)benzofuran

Chemical Property of 1-benzofuran-3-ylMethanaMine

Chemical Property:

• Boiling Point: 254.3±15.0 °C(Predicted)
• PKA: 9.07±0.29(Predicted)
• PSA: 39.16000
• Density: 1.164±0.06 g/cm3(Predicted)
• LogP: 2.59180

Purity/Quality:

97% ^*data from raw suppliers

3-(Aminomethyl)benzofuran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-benzofuran-3-ylMethanaMine

There total 6 articles about 1-benzofuran-3-ylMethanaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

benzofuran-3-carboxaldehyde oxime (391858-97-2) → benzofuran-3-ylmethanamine (165735-63-7)

Guidance literature:

With acetic acid; zinc; at 20 ℃; for 6h;

Reference yield: 30.0%

1-benzofuran-3-carbaldehyde (4687-25-6) → benzofuran-3-ylmethanamine (165735-63-7)

Guidance literature:

With ammonia; sodium tris(acetoxy)borohydride; In tetrahydrofuran; dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.7b01300

Reference yield:

benzofuran-3-carboxamide (959304-51-9) → benzofuran-3-ylmethanamine (165735-63-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 16h;

upstream raw materials:

benzofuran-3-carboxaldehyde oxime

benzofuran-3-carboxamide

1-benzofuran-3-carbaldehyde

3-hydroxymethylbenzofuran