6-bromo-1-[2-chloro-4-(pentyloxy)benzyl]-2,4-dimethyl-1H-benzimidazole

Base Information

• Chemical Name: 6-bromo-1-[2-chloro-4-(pentyloxy)benzyl]-2,4-dimethyl-1H-benzimidazole
• CAS No.: 808745-01-9
• Molecular Formula: C21H24BrClN2O
• Molecular Weight: 435.791
• Mol file: 808745-01-9.mol

Synonyms:6-bromo-1-[2-chloro-4-(pentyloxy)benzyl]-2,4-dimethyl-1H-benzimidazole

Chemical Property of 6-bromo-1-[2-chloro-4-(pentyloxy)benzyl]-2,4-dimethyl-1H-benzimidazole

Chemical Property:

• PSA: 27.05000
• LogP: 6.68630

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-bromo-1-[2-chloro-4-(pentyloxy)benzyl]-2,4-dimethyl-1H-benzimidazole

There total 3 articles about 6-bromo-1-[2-chloro-4-(pentyloxy)benzyl]-2,4-dimethyl-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-3-methylbenzene-1,2-diamine (76153-06-5) → 6-bromo-1-[2-chloro-4-(pentyloxy)benzyl]-2,4-dimethyl-1H-benzimidazole (808745-01-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / 3 h / 20 - 150 °C

1.2: 2 h / Heating / reflux

2.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 60 h / 50 °C

With potassium carbonate; acetic acid; In DMF (N,N-dimethyl-formamide);

Reference yield:

2-chloro-4-(1-pentyloxy)benzyl bromide (275384-50-4) + 6-bromo-2,4-dimethyl-1H-benzimidazole → 6-bromo-1-[2-chloro-4-(pentyloxy)benzyl]-2,4-dimethyl-1H-benzimidazole (808745-01-9)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 50 ℃; for 60h;

Reference yield:

4-bromo-2-methyl-6-nitroaniline (77811-44-0) → 6-bromo-1-[2-chloro-4-(pentyloxy)benzyl]-2,4-dimethyl-1H-benzimidazole (808745-01-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water; iron; ammonium chloride / tetrahydrofuran; ethanol / 2 h / Heating / reflux

2.1: acetic acid / 3 h / 20 - 150 °C

2.2: 2 h / Heating / reflux

3.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 60 h / 50 °C

With water; iron; potassium carbonate; ammonium chloride; acetic acid; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol;

upstream raw materials:

2-chloro-4-(1-pentyloxy)benzyl bromide

5-bromo-3-methylbenzene-1,2-diamine

4-bromo-2-methyl-6-nitroaniline