5-Bromo-1-chloro-2,3-difluorobenzene

Base Information

• Chemical Name: 5-Bromo-1-chloro-2,3-difluorobenzene
• CAS No.: 1060813-07-1
• Molecular Formula: C6H2BrClF2
• Molecular Weight: 227.436
• Hs Code.: 2903998090
• Mol file: 1060813-07-1.mol

Synonyms:5-Bromo-1-chloro-2,3-difluorobenzene

Chemical Property of 5-Bromo-1-chloro-2,3-difluorobenzene

Chemical Property:

• Boiling Point: 192.3±35.0 °C(Predicted)
• PSA: 0.00000
• Density: 1.805±0.06 g/cm3(Predicted)
• LogP: 3.38070

Purity/Quality:

96% ^*data from raw suppliers

5-Bromo-1-chloro-2,3-difluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-1-chloro-2,3-difluorobenzene

There total 2 articles about 5-Bromo-1-chloro-2,3-difluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.3%

3-chloro-4,5-difiuoro-aniline (149144-05-8) → 5-bromo-1-chloro-2,3-difluorobenzene (1060813-07-1)

Guidance literature:

With hydrogen bromide; copper(I) bromide; sodium nitrite; In water; at 0 - 60 ℃;

Reference yield:

1-Chloro-2,3-difluoro-5-nitrobenzene (53780-44-2) → 5-bromo-1-chloro-2,3-difluorobenzene (1060813-07-1)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; acetic acid / methanol / 2 h / 60 - 65 °C

2: sodium nitrite; copper(I) bromide; hydrogen bromide / water / 0 - 60 °C

With hydrogen bromide; iron; acetic acid; copper(I) bromide; sodium nitrite; In methanol; water;

Reference yield: 84.0%

5-bromo-1-chloro-2,3-difluorobenzene (1060813-07-1) → 3-chloro-4,5-difluorophenol

Guidance literature:

With 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium hydroxide; In 1,4-dioxane; water; at 100 ℃; for 16h; Inert atmosphere;

upstream raw materials:

1-Chloro-2,3-difluoro-5-nitrobenzene

3-chloro-4,5-difiuoro-aniline

Downstream raw materials:

5-(5-(3-chloro-4,5-difluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

2-(3-chloro-4,5-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

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